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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis

Fig. 4

Aberrant deposition of elastic fibers in CPEB2-deficient lungs. a Detection of MYFs by αSMA-immunostaining in P7 CP2WT and CP2KO lungs. The alveolar structure is outlined by dashed lines. MYFs on the tips of septa and alveolar walls are denoted by arrowheads and arrows, respectively. b Histological morphology of elastic fibers in CP2WT and CP2KO lungs at different postnatal days. c The number of elastin-positive septal tips, density and length of elastic fibers in CP2WT and CP2KO alveoli (5 mice per group, representative images in b) at indicated postnatal ages. Data are mean ± s.e.m., *P < 0.05, **P < 0.01, and ***P < 0.001, by two-way ANOVA and Bonferroni post-hoc test, Scales, 100 μm

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