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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: MiR-30a and miR-379 modulate retinoic acid pathway by targeting DNA methyltransferase 3B in oral cancer

Fig. 1

Downexpression of ADHFE1 and ALDH1A2 in OSCC tissues. a Heat map of the 10 differentially expressed mRNA, including DNMT families and retinoid signaling related genes in 40 OSCC tissue pairs (GSE37991). Red, overexpression; green, downexpression. b Validation of ADHFE1 and ALDH1A2 expression by qRT-PCR in another 33 of OSCC tumors (T) compared with their own adjacent normal tissues (N). Expression levels are expressed as the log2 ratios. Red lines are represented as group mean value; p < 0.0001. c-d Immunohistochemical staining of ADHFE1 and ALDH1A2 expression in human OSCC specimens. Top left, HE staining of a representative OSCC specimen, showing both adjacent normal oral epithelium (Epi) and underlying tumor nests (T) (scale bar, 500 μm). Top right, ADHFE1 or ALDH1A2 staining on the same region, demonstrating strong ADHFE1 or ALDH1A2 expression at the basal cell layer of the adjacent normal oral epithelium (Epi) and in the infiltrating tumor cells (T). Bottom left, results of ADHFE1 scoring grade for the 36 OSCC specimens pairs and ALDH1A2 scoring grade for the 38 OSCC specimens pairs. Bottom right, comparing of staining intensity between nontumor (N) and tumor (T) in the OSCC specimen

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