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Table 1 Hemagglutinin cleavage site and NAI resistance marker in wild-type viruses and CVVs

From: Development of high-growth influenza H7N9 prepandemic candidate vaccine viruses in suspension MDCK cells

CVVsWild-type virusesPathogenicityModification of hemagglutinin cleavage siteModification of NAI resistance marker (R292K)
Wild typeCVVsWild typeCVVs
NHRI-RG3A/Guangdong/17SF003/2016HPAIPEVPKRKRTAR/GLFPEVPKGR/GLFKR
NHRI-RG4A/Hong Kong/125/2017LPAIPEIPKGR/GLFPEIPKGR/GLFRR
NHRI-RG5A/Guangdong/SP440/2017HPAIPEVPKRKRTAR/GLFPEVPKGR/GLFKR
NHRI-RG6A/Taiwan/1/2017HPAIPEVPKRKRTAR/GLFPEVPKGR/GLFKR
  1. Note: HPAI highly pathogenic avian influenza, LPAI low pathogenic avian influenza, NAI neuraminidase inhibitor