Skip to main content
Fig. 5 | Journal of Biomedical Science

Fig. 5

From: Recombinant lipidated Zika virus envelope protein domain III elicits durable neutralizing antibody responses against Zika virus in mice

Fig. 5

Neutralizing antibody responses induced by rLZE3 do not cross-neutralize dengue-2 virus. Groups of C57BL/6 mice (n = 4) were immunized subcutaneously with PBS, rZE3, or rLZE3 (10 μg per dose) twice at a two-week interval. Live Zika virus or dengue-2 virus was injected intraperitoneally in parallel. Serum samples were collected from immunized mice at 8 weeks after the first immunization. The Zika virus- or dengue-2 virus-neutralizing capacity of the serum samples was determined by FRNT. The neutralizing antibody titer was calculated as the reciprocal of the highest dilution that resulted in a 50% reduction in FFUs compared to the FFUs of control samples containing the virus alone

Back to article page

Journal of Biomedical Science

ISSN: 1423-0127