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Table 1 LncRNAs implicated in the pathogenesis of cardiac hypertrophy and heart failure

From: Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases

LncRNA Target Physiological/pathological impact Mechanism involved
Mhrt [32, 33] Brg1 Protective against pathological cardiac hypertrophy 1. Inhibit Brg1-Hdac-Parp chromatin repressor complex to prohibit initiation of Myh6-to-Myh7 switch
2. Reduce myocardin acetylation/expression via HDAC5
Chast [29] Plekhm1 Promotes cardiac hypertrophy Activated by NFAT signaling and downregulates Plekhm1 to induce cardiac remodeling processes
Chaer [30] PCR2 Increases pro-hypertrophic gene expression Interact with PCR2 to disinhibit hypertrophic gene expression
CHRF [34, 35] 1. miR-489
2. miR-93
Induces cardiac hypertrophic responses 1. Sponge miR-489 to increase expression of Myd88
2. Sponge miR-93 to disinhibit PI3K/Akt pathway
MIAT [36,37,38, 48] 1. miR-150
2. miR-93
3. miR-24
Contributing factor to the pathogenesis of cardiac hypertrophy, myocardial infarction and cardiac fibrosis 1. Sponge miR-150 to increase expression of P300
2. Sponge miR-93 to activate PI3K/Akt/mTOR pathway via TLR4
3. Sponge anti-fibrotic miR-24
HOTAIR [40] miR-19 Inhibiting progress of cardiac hypertrophy Sponge miR-19 to derepress PTEN expression
lncRNA-ROR [41] miR-133 Promoting fetal genes and cardiomyocyte growth Sponge miR-133
MAGI1-IT1 [42] miR-302e Protective against cardiac hypertrophy Sponge miR-302e to derepress DKK1 and inactivate Wnt/beta-catenin signaling
Meg3 [43] miR-361-5p Promotes cardiac hypertrophy Activated by STAT3 to sponge miR-361-5p and derepress HDAC9
Plscr4 [44] miR-214 Protective against cardiac hypertrophy Sponge miR-214 to derepress Mfn2
SYNE1-AS1 [45] miR-525-5p Promoting cardiac hypertrophy Activated by SP1 to sponge miR-525-5p to derepress SP1, forming positive feedback loop
XIST [46, 47] 1. miR-101
2. miR-330-3p
1. Regulating cardiac hypertrophy
2. Attenuating cardiac hypertrophy
1. Sponge miR-101 to derepress TLR2
2. Sponge miR-330-3p to derepress S100B