From: Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases
LncRNA | Target | Physiological/pathological impact | Mechanism involved |
---|---|---|---|
Brg1 | Protective against pathological cardiac hypertrophy | 1. Inhibit Brg1-Hdac-Parp chromatin repressor complex to prohibit initiation of Myh6-to-Myh7 switch 2. Reduce myocardin acetylation/expression via HDAC5 | |
Chast [29] | Plekhm1 | Promotes cardiac hypertrophy | Activated by NFAT signaling and downregulates Plekhm1 to induce cardiac remodeling processes |
Chaer [30] | PCR2 | Increases pro-hypertrophic gene expression | Interact with PCR2 to disinhibit hypertrophic gene expression |
1. miR-489 2. miR-93 | Induces cardiac hypertrophic responses | 1. Sponge miR-489 to increase expression of Myd88 2. Sponge miR-93 to disinhibit PI3K/Akt pathway | |
1. miR-150 2. miR-93 3. miR-24 | Contributing factor to the pathogenesis of cardiac hypertrophy, myocardial infarction and cardiac fibrosis | 1. Sponge miR-150 to increase expression of P300 2. Sponge miR-93 to activate PI3K/Akt/mTOR pathway via TLR4 3. Sponge anti-fibrotic miR-24 | |
HOTAIR [40] | miR-19 | Inhibiting progress of cardiac hypertrophy | Sponge miR-19 to derepress PTEN expression |
lncRNA-ROR [41] | miR-133 | Promoting fetal genes and cardiomyocyte growth | Sponge miR-133 |
MAGI1-IT1 [42] | miR-302e | Protective against cardiac hypertrophy | Sponge miR-302e to derepress DKK1 and inactivate Wnt/beta-catenin signaling |
Meg3 [43] | miR-361-5p | Promotes cardiac hypertrophy | Activated by STAT3 to sponge miR-361-5p and derepress HDAC9 |
Plscr4 [44] | miR-214 | Protective against cardiac hypertrophy | Sponge miR-214 to derepress Mfn2 |
SYNE1-AS1 [45] | miR-525-5p | Promoting cardiac hypertrophy | Activated by SP1 to sponge miR-525-5p to derepress SP1, forming positive feedback loop |
1. miR-101 2. miR-330-3p | 1. Regulating cardiac hypertrophy 2. Attenuating cardiac hypertrophy | 1. Sponge miR-101 to derepress TLR2 2. Sponge miR-330-3p to derepress S100B |