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Table 2 LncRNAs linked to myocardial infarction

From: Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases

LncRNA

Target

Physiological/pathological impact

Mechanism involved

CAIF [50]

P53

Preventing detrimental autophagy and cell death of cardiomyocytes

Block p53 from activating myocardin transcription

BACE1-AS [51]

BACE1

Increases expression of toxic β-amyloid protein in endothelial cells and cardiomyocytes

Stabilize β-secretase-1 (BACE1) sense transcript to increase β-amyloid protein production

CARL [52]

miR-539

Regulates mitochondrial fission and apoptosis

Sponge miR-539 to derepress PHB2 expression

APF [53]

miR-188-3p

Induces adaptive cell autophagy after MI

Sponge miR-188-3p to derepress ATG7 expression

NRF [54]

miR-873

Regulates programmed cardiomyocyte necrosis pathways

Activated by p53 to sponge miR-873 and derepress RIPK1/RIPK3 expression