From: Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases
LncRNA | Target | Physiological/pathological impact | Mechanism involved |
---|---|---|---|
CAIF [50] | P53 | Preventing detrimental autophagy and cell death of cardiomyocytes | Block p53 from activating myocardin transcription |
BACE1-AS [51] | BACE1 | Increases expression of toxic β-amyloid protein in endothelial cells and cardiomyocytes | Stabilize β-secretase-1 (BACE1) sense transcript to increase β-amyloid protein production |
CARL [52] | miR-539 | Regulates mitochondrial fission and apoptosis | Sponge miR-539 to derepress PHB2 expression |
APF [53] | miR-188-3p | Induces adaptive cell autophagy after MI | Sponge miR-188-3p to derepress ATG7 expression |
NRF [54] | miR-873 | Regulates programmed cardiomyocyte necrosis pathways | Activated by p53 to sponge miR-873 and derepress RIPK1/RIPK3 expression |