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Table 2 LncRNAs linked to myocardial infarction

From: Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases

LncRNA Target Physiological/pathological impact Mechanism involved
CAIF [50] P53 Preventing detrimental autophagy and cell death of cardiomyocytes Block p53 from activating myocardin transcription
BACE1-AS [51] BACE1 Increases expression of toxic β-amyloid protein in endothelial cells and cardiomyocytes Stabilize β-secretase-1 (BACE1) sense transcript to increase β-amyloid protein production
CARL [52] miR-539 Regulates mitochondrial fission and apoptosis Sponge miR-539 to derepress PHB2 expression
APF [53] miR-188-3p Induces adaptive cell autophagy after MI Sponge miR-188-3p to derepress ATG7 expression
NRF [54] miR-873 Regulates programmed cardiomyocyte necrosis pathways Activated by p53 to sponge miR-873 and derepress RIPK1/RIPK3 expression