Table 3 LncRNAs contributing to cardiac fibrosis
From: Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases
LncRNA | Target | Physiological/pathological impact | Mechanism involved |
|---|---|---|---|
WISPER [55] | Â | Promoting cardiac fibrosis | Promotes differentiation and proliferation of cardiac fibroblasts by interacting with TIA1-related protein and regulation of lysyl hydroylase 2 |
MEG3 [56] | MMP2 | Promoting cardiac fibrosis | Required for TGFβ-mediated, P53-dependent MMP-2 transcriptional activity |
MALAT1 [57] | miR-145 | Promoting cardiac fibrosis | Promotes fibroblast activity and collagen production by downregulating miR-145, a negative regulator of TGFβ |
MIAT1 [48] | miR-24 | Promoting cardiac fibrosis | Increases fibrosis by sponging miR-24 |