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Table 3 LncRNAs contributing to cardiac fibrosis

From: Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases

LncRNATargetPhysiological/pathological impactMechanism involved
WISPER [55] Promoting cardiac fibrosisPromotes differentiation and proliferation of cardiac fibroblasts by interacting with TIA1-related protein and regulation of lysyl hydroylase 2
MEG3 [56]MMP2Promoting cardiac fibrosisRequired for TGFβ-mediated, P53-dependent MMP-2 transcriptional activity
MALAT1 [57]miR-145Promoting cardiac fibrosisPromotes fibroblast activity and collagen production by downregulating miR-145, a negative regulator of TGFβ
MIAT1 [48]miR-24Promoting cardiac fibrosisIncreases fibrosis by sponging miR-24