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Table 4 LncRNAs reported to regulate cardiac arrhythmias and electrical remodeling

From: Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases

LncRNATargetPhysiological/pathological impactMechanism involved
TCONS_0007546 [58, 59]miR-328Reduces atrial fibrillation inducibilityFunctions as a sponge of miR-328 to derepress CACNA1C expression
MALAT1 [61, 62]miR-200cReduces Kv4.2 & Kv4.3 expression→ reduced ItoSponging miR-200c to derepress HMGB1 expression
Kcna2-AS [63]Kcna2Increases susceptibility to ventricular arrhythmia in failing heartReducing Kcna2 → reduced IKs → APs prolongation in rat failing heart
CCRR [64]CIP85Preserving cardiac Cx43 expression, conduction and contractile functionForms complex with CIP85 and prevents CIP85-mediated Cx43 endocytosis and degradation
ZFAS1 [65]SERCA2aUpregulated in ischemic HF, causing impaired contractile functionRepress SERCA2a expression and availability, leading to intracellular Ca2+ overload
Sacrolamban (Scl) [69]SERCAMediating the calcium reuptake in cardiomyocytes of Drosophila
DWORF [70, 71]PLN, SLN, or MLNEnhance cardiac contractilityDecrease the time of individual contraction-relaxation cycle