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Table 8 LncRNAs as biomarkers for cardiovascular diseases

From: Expedition to the missing link: Long noncoding RNAs in cardiovascular diseases

LncRNAClinical ApplicationPhysiological/pathological impactMechanism involved
CoroMarker [132, 133]Diagnosis of CADDecrease pro-inflammatory cytokine secretion from THP-1 monocytic cellsUnknown
LIPCAR [135]Prediction of cardiac remodelingAssociated with future development of cardiac remodelingUnknown
GAS5 [136,137,138]↑ in arterial plaques
↓ in plasma of CAD patients
Modulate macrophages and ECs apoptosis after ox-LDL stimulationUnknown
SENCR [139,140,141]Diagnosis of early onset CAD:
↓ in circulating ECs
↑ in monocytes
Regulation of commitment from pluripotent cells and angiogenic capacity of ECRegulate myocardin gene regulation to stabilize the contractile state of VSMCs
DKFZP434I0714 [144]Prediction of adverse CV events in uremic patientsModulate stress-induced EC apoptosis, endothelial dysfunction, and vascular inflammationUnknown