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Table 4 Comparison of oral rotavirus vaccines

From: Rotavirus infection in children in Southeast Asia 2008–2018: disease burden, genotype distribution, seasonality, and vaccination

Rotavirus Vaccines Rotarix® (GSK) [100] RotaTeq® (Merck) [100] Rotavac® (Bharat Biotech) [112] RotaSIIL® (Serum) [116] Rotavin (Polyvac) [120] LLR (Lanzhou) [118, 119] RV3-BB (Bio Farma) [121]
Licensure Several countries, 2006 Several countries, 2006 India, 2014 India, 2017 Vietnam, 2012 China, 2000 Clinical trial phase IIb
Prequalification Yes Yes Yes Yes No No No
Strains Monovalent, human derived G1P[8] Pentavalent, WC3 G6P[5] bovine reassortant G1–4,P8 Monovalent, human neonatal derived G9P[11] Pentavalent, UK Bovine G6P[5], reassortant G1–4, G9 Monovalent, human G1P[8] Monovalent, Lamb G10P[12] Monovalent, human neonatal G3P[6]
Number of doses 2 3 3 3 2 3 3
Age, first dose 6 weeks 6 weeks 6 weeks 6 weeks 6 weeks 2 months New born: 0–5 days Infant: 8 weeks
Age, last dose 10 weeks 14 weeks 14 weeks 14 weeks 14 weeks 36 months New born: 14 week Infant: 18 weeks
Dosage 106 median CCID50 of live attenuated human G1P[8] RV 2.0–2.8 × 106 infectious units per reassortant 105 fluorescent focus unit (FFU) of live rotavirus 105.6 infectious units per reassortant 106.3 FFU/dose of live attenuated human G1P[8] particles > 5.5 log CCID50 8.3–8.7 × 106 FCFU/ml
UNICEF price per course for GAVI-supported countries, 2020 [122] $4.58 $9.60 (RotaTeq is no longer an option available to GAVI-supported countries) $2.55 $4.65 (1-dose vial) $2.85 (2-dose vial) $17.60 $72 for the three-dose series