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Table 4 Comparison of oral rotavirus vaccines

From: Rotavirus infection in children in Southeast Asia 2008–2018: disease burden, genotype distribution, seasonality, and vaccination

Rotavirus Vaccines

Rotarix® (GSK) [100]

RotaTeq® (Merck) [100]

Rotavac® (Bharat Biotech) [112]

RotaSIIL® (Serum) [116]

Rotavin (Polyvac) [120]

LLR (Lanzhou) [118, 119]

RV3-BB (Bio Farma) [121]

Licensure

Several countries, 2006

Several countries, 2006

India, 2014

India, 2017

Vietnam, 2012

China, 2000

Clinical trial phase IIb

Prequalification

Yes

Yes

Yes

Yes

No

No

No

Strains

Monovalent, human derived G1P[8]

Pentavalent, WC3 G6P[5] bovine reassortant G1–4,P8

Monovalent, human neonatal derived G9P[11]

Pentavalent, UK Bovine G6P[5], reassortant G1–4, G9

Monovalent, human G1P[8]

Monovalent, Lamb G10P[12]

Monovalent, human neonatal G3P[6]

Number of doses

2

3

3

3

2

3

3

Age, first dose

6 weeks

6 weeks

6 weeks

6 weeks

6 weeks

2 months

New born: 0–5 days Infant: 8 weeks

Age, last dose

10 weeks

14 weeks

14 weeks

14 weeks

14 weeks

36 months

New born: 14 week Infant: 18 weeks

Dosage

106 median CCID50 of live attenuated human G1P[8] RV

2.0–2.8 × 106 infectious units per reassortant

105 fluorescent focus unit (FFU) of live rotavirus

105.6 infectious units per reassortant

106.3 FFU/dose of live attenuated human G1P[8] particles

> 5.5 log CCID50

8.3–8.7 × 106 FCFU/ml

UNICEF price per course for GAVI-supported countries, 2020 [122]

$4.58

$9.60 (RotaTeq is no longer an option available to GAVI-supported countries)

$2.55

$4.65 (1-dose vial) $2.85 (2-dose vial)

$17.60

$72 for the three-dose series