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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Ab locks for improving the selectivity and safety of antibody drugs

Fig. 1

Schematic of pro-antibody selectively activated at the disease region by installing a protease-cleavable Ab lock. (1) Generation of pro-antibody (pro-Ab) by installing a protease-cleavable Ab lock is a novel and advanced recombinant Ab-based strategy that (2) selectively “turns on” the mAb activity when the pro-Ab reaches proteolytic enzyme (i.e., protease)-overexpressed diseased tissue, (3) locally neutralizing the target antigen and reducing on-target toxicity caused by systemic administration of Ab drugs during disease treatment. Ab, antibody; Ag, antigen

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