Molecular networking in the neuronal ceroid lipofuscinoses: insights from mammalian models and the social amoeba Dictyostelium discoideum

Table 2 Interactions between NCL proteins in mammals

Protein 1	Protein 2	Effect	Sample	Reference
PPT1/CLN1	CTSD/CLN10	Interaction	SH-SY5Y human neuroblastoma cells	Scifo et al., 2013 [59]
CLN5	TPP1/CLN2	Interaction	COS-1 cells	Vesa et al., 2002 [77]
CLN5	CLN3	Interaction	COS-1 cells	Vesa et al., 2002 [77]
CLN5	PPT1/CLN1	Interaction	Mouse brain extract COS-1 cells (author note: place on a separate line under "Mouse brain extract") HeLa cells (author note: place on a separate line under "COS-1 cells")	Lyly et al., 2009 [78]
	TPP1/CLN2
	CLN3
	CLN6
	CLN8
CTSD/CLN10	PGRN/CLN11	Interaction	HEK293T cells	Zhou et al., 2017; Valdez et al., 2017 [79, 80]
PPT1/CLN1	DNAJC5/CLN4	PPT1/CLN1 depalmitoylates DNAJC5/CLN4	PPT1/CLN1 from HEK293T cell media depalmitoylated DNAJC5/CLN4 isolated from mouse brain	Henderson et al., 2016 [81]
PPT1/CLN1	CLN5	PPT1/CLN1 regulates the trafficking of CLN5	HeLa cells	Lyly et al., 2009 [78]
CLN3	CTSD/CLN10	Co-localization under hypertonic conditions	Baby hamster kidney cells	Cárcel-Trullols et al., 2017 [82]
Increased expression of CLN3 under hypertonic conditions	CTSD/CLN10	Decreased activity of CTSD/CLN10	Baby hamster kidney cells	Cárcel-Trullols et al., 2017 [82]
CLN5	CTSD/CLN10	CLN5 regulates the processing of CTSD/CLN10	CLN5 (N320S) expressed in HeLa cells reduced the processing of CTSD/CLN10 to its enzymatically active form	Qureshi et al., 2018 [83]
PGRN/CLN11	CTSD/CLN10	PGRN/CLN11 increases the activity of CTSD/CLN10	Human PGRN and CTSD/CLN10 from bovine spleen	Valdez et al., 2017 [80]

ISSN: 1423-0127