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Table 2 Interactions between NCL proteins in mammals

From: Molecular networking in the neuronal ceroid lipofuscinoses: insights from mammalian models and the social amoeba Dictyostelium discoideum

Protein 1 Protein 2 Effect Sample Reference
PPT1/CLN1 CTSD/CLN10 Interaction SH-SY5Y human neuroblastoma cells Scifo et al., 2013 [59]
CLN5 TPP1/CLN2 Interaction COS-1 cells Vesa et al., 2002 [77]
CLN3
CLN5 PPT1/CLN1 Interaction Mouse brain extract COS-1 cells (author note: place on a separate line under "Mouse brain extract") HeLa cells (author note: place on a separate line under "COS-1 cells") Lyly et al., 2009 [78]
TPP1/CLN2  
CLN3  
CLN6
CLN8
CTSD/CLN10 PGRN/CLN11 Interaction HEK293T cells Zhou et al., 2017; Valdez et al., 2017 [79, 80]
PPT1/CLN1 DNAJC5/CLN4 PPT1/CLN1 depalmitoylates DNAJC5/CLN4 PPT1/CLN1 from HEK293T cell media depalmitoylated DNAJC5/CLN4 isolated from mouse brain Henderson et al., 2016 [81]
PPT1/CLN1 CLN5 PPT1/CLN1 regulates the trafficking of CLN5 HeLa cells Lyly et al., 2009 [78]
CLN3 CTSD/CLN10 Co-localization under hypertonic conditions Baby hamster kidney cells Cárcel-Trullols et al., 2017 [82]
Increased expression of CLN3 under hypertonic conditions CTSD/CLN10 Decreased activity of CTSD/CLN10 Baby hamster kidney cells Cárcel-Trullols et al., 2017 [82]
CLN5 CTSD/CLN10 CLN5 regulates the processing of CTSD/CLN10 CLN5 (N320S) expressed in HeLa cells reduced the processing of CTSD/CLN10 to its enzymatically active form Qureshi et al., 2018 [83]
PGRN/CLN11 CTSD/CLN10 PGRN/CLN11 increases the activity of CTSD/CLN10 Human PGRN and CTSD/CLN10 from bovine spleen Valdez et al., 2017 [80]