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Table 4 Gene-deficiency phenotypes in Dictyostelium NCL gene knockout models

From: Molecular networking in the neuronal ceroid lipofuscinoses: insights from mammalian models and the social amoeba Dictyostelium discoideum

Phenotype Cell Line
tpp1A cln3 cln5 mfsd8
Storage body accumulation Yes Yes Yes Not tested
Aberrant cell proliferation No (Yes, tpp1 knockdown) Yes Not tested Not tested
Impaired cytokinesis Not tested Yes Not tested Not tested
Defects in osmoregulation Not tested Yes Not tested Not tested
Impaired autophagy Yes Not tested Not tested Not tested
Reduced chemotaxis Not tested Yes Yes Not tested
Aberrant secretion Not tested Yes Not tested Yes
Reduced adhesion Not tested Yes Yes Not tested
Delayed aggregation Not tested Yes Not tested Not tested
Precocious development Yes Yes Not tested Not tested
Impaired spore formation Yes Not tested Not tested Not tested
Impaired spore integrity Not tested Yes Not tested Not tested