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Table 4 Gene-deficiency phenotypes in Dictyostelium NCL gene knockout models

From: Molecular networking in the neuronal ceroid lipofuscinoses: insights from mammalian models and the social amoeba Dictyostelium discoideum

Phenotype

Cell Line

tpp1A−

cln3−

cln5−

mfsd8−

Storage body accumulation

Yes

Yes

Yes

Not tested

Aberrant cell proliferation

No (Yes, tpp1 knockdown)

Yes

Not tested

Not tested

Impaired cytokinesis

Not tested

Yes

Not tested

Not tested

Defects in osmoregulation

Not tested

Yes

Not tested

Not tested

Impaired autophagy

Yes

Not tested

Not tested

Not tested

Reduced chemotaxis

Not tested

Yes

Yes

Not tested

Aberrant secretion

Not tested

Yes

Not tested

Yes

Reduced adhesion

Not tested

Yes

Yes

Not tested

Delayed aggregation

Not tested

Yes

Not tested

Not tested

Precocious development

Yes

Yes

Not tested

Not tested

Impaired spore formation

Yes

Not tested

Not tested

Not tested

Impaired spore integrity

Not tested

Yes

Not tested

Not tested