Fig. 6

Notch pathway inhibitor DAPT rescues defective angiogenesis caused by knockdown of METTL3. a qRT-PCR and (b) western blot analysis of expression of target genes in control and METTL3 deficient endothelial cells which were treated with DMSO or DAPT, respectively. c Tube formation and (g) migration assay of control and METTL3 depletion cells after DMSO or DAPT treatment, respectively. Data are shown as mean ± SEM of three independent experiments. P values were calculated using two-way ANOVA followed by Student’s t-test. M, METTL3; D, DAPT; M × D, METTL3 × DAPT. *, P < 0.05; **, P < 0.01; ***, P < 0.001