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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats

Fig. 7

Knockdown TGR5 or BRCA1 abolished the protective effects of INT777 on BBB permeability after MCAO. a Representative Western blots. b Quantitative analyses of TGR5, BRCA1, Sirt1, zo-1, occludin. Quantified infarct ratio (c), neurological scores (d) and brain water content (e), n = 6 per group. *P < 0.05 vs sham, #P < 0.05 vs MCAO+ vehicle,@P < 0.05 vs MCAO+INT777 + Scr siRNA group. Scr siRNA, scramble siRNA

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