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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Pathophysiological implications of hypoxia in human diseases

Fig. 2

Hypoxia-regulated cancer progression. Hypoxia is a typical feature of tumor microenvironment, which contributes to initial tumorigenesis, induced angiogenesis, drug resistance, and cancer metastasis. The major upstream regulators (gray), functional downstream genes (blue), and resulting cellular consequences (yellow) under the control of hypoxia signaling are indicated

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