Fig. 6
From: Pathophysiological implications of hypoxia in human diseases
Impacts of hypoxia on endometriosis pathogenesis. Shed-off endometrial tissues will immediately suffer hypoxic stress when it retrogrades into the peritoneal cavity during menstruation. Hypoxia regulates numerous downstream target genes involved in different cellular processes including cell survival, metabolism, angiogenesis, E2 and PGE2 production, and cell adhesion to help the development of endometriosis