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Fig. 9 | Journal of Biomedical Science

Fig. 9

From: Statin inhibits large hepatitis delta antigen-Smad3 -twist-mediated epithelial-to-mesenchymal transition and hepatitis D virus secretion

Fig. 9

Simvastatin treatment suppresses TGF-β secretion and EMT phenotype in HBV/HDV-co-transfected Huh7 cell model. Cells were transfected with HBV- and HDV-expressing plasmids, and then treated with 5 or 25 μM simvastatin in 2% FBS medium (a) After 3 days of statin treatment, TGF-β levels of supernatants were analyzed by ELISA. TGF-β secretion was notably reduced by high-dose (25 μM) simvastatin treatment. b-c After 9 days of statin treatment, levels of E-cadherin and N-cadherin were analyzed by Western blotting. Hsp70 was used as internal control. Results shown are based on three independent experiments. *: p < 0.05; **: p < 0.01

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