Skip to main content
Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure

Fig. 7

Reprogramming hypertension in young HFD offspring by simvastatin and metformin. Changes in (a) SBP and sympathetic vasomotor activity at age of 12 weeks or (b) SBP at age of 18 weeks in ND or HFD offspring following 4-week treatment with simvastatin (5 mg·kg− 1·day− 1) or metformin (400 mg·kg− 1·day− 1), administered via gastric gavage at age of 8 weeks for 4 weeks. Data are presented as mean ± SEM (n = 6–8 per group). *P < 0.05 versus ND group and #P < 0.05 versus HFD group in post hoc Newman-Keuls multiple-range test

Back to article page

Journal of Biomedical Science

ISSN: 1423-0127