TY - JOUR AU - Boni, C. AU - Fisicaro, P. AU - Valdatta, C. AU - Amadei, B. AU - Vincenzo, P. AU - Giuberti, T. PY - 2007 DA - 2007// TI - Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection JO - J Virol VL - 81 UR - https://doi.org/10.1128/JVI.02844-06 DO - 10.1128/JVI.02844-06 ID - Boni2007 ER - TY - JOUR AU - Bengsch, B. AU - Martin, B. AU - Thimme, R. PY - 2014 DA - 2014// TI - Restoration of HBV-specific CD8+ T cell function by PD-1 blockade in inactive carrier patients is linked to T cell differentiation JO - J Hepatol VL - 61 UR - https://doi.org/10.1016/j.jhep.2014.07.005 DO - 10.1016/j.jhep.2014.07.005 ID - Bengsch2014 ER - TY - JOUR AU - Schuch, A. AU - Salimi Alizei, E. AU - Heim, K. AU - Wieland, D. AU - Kiraithe, M. M. AU - Kemming, J. PY - 2019 DA - 2019// TI - Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load JO - Gut. VL - 68 UR - https://doi.org/10.1136/gutjnl-2018-316641 DO - 10.1136/gutjnl-2018-316641 ID - Schuch2019 ER - TY - JOUR AU - Burton, A. R. AU - Pallett, L. J. AU - McCoy, L. E. AU - Suveizdyte, K. AU - Amin, O. E. AU - Swadling, L. PY - 2018 DA - 2018// TI - Circulating and intrahepatic antiviral B cells are defective in hepatitis B JO - J Clin Invest VL - 128 UR - https://doi.org/10.1172/JCI121960 DO - 10.1172/JCI121960 ID - Burton2018 ER - TY - JOUR AU - Gehring, A. J. AU - Protzer, U. PY - 2019 DA - 2019// TI - Targeting innate and adaptive immune responses to cure chronic HBV infection JO - Gastroenterology. VL - 156 UR - https://doi.org/10.1053/j.gastro.2018.10.032 DO - 10.1053/j.gastro.2018.10.032 ID - Gehring2019 ER - TY - JOUR AU - Maini, M. K. AU - Pallett, L. J. PY - 2018 DA - 2018// TI - Defective T-cell immunity in hepatitis B virus infection: why therapeutic vaccination needs a helping hand JO - Lancet Gastroenterol Hepatol VL - 3 UR - https://doi.org/10.1016/S2468-1253(18)30007-4 DO - 10.1016/S2468-1253(18)30007-4 ID - Maini2018 ER - TY - JOUR AU - Boni, C. AU - Janssen, H. L. A. AU - Rossi, M. AU - Yoon, S. K. AU - Vecchi, A. AU - Barili, V. PY - 2019 DA - 2019// TI - Combined GS-4774 and tenofovir therapy can improve HBV-specific T-cell responses in patients with chronic hepatitis JO - Gastroenterology VL - 157 UR - https://doi.org/10.1053/j.gastro.2019.03.044 DO - 10.1053/j.gastro.2019.03.044 ID - Boni2019 ER - TY - JOUR AU - Ma, Z. AU - Zhang, E. AU - Gao, S. AU - Xiong, Y. AU - Lu, M. PY - 2019 DA - 2019// TI - Toward a functional cure for hepatitis B: the rationale and challenges for therapeutic targeting of the B cell immune response JO - Front Immunol VL - 10 UR - https://doi.org/10.3389/fimmu.2019.02308 DO - 10.3389/fimmu.2019.02308 ID - Ma2019 ER - TY - JOUR AU - Mueller, S. N. AU - Ahmed, R. PY - 2009 DA - 2009// TI - High antigen levels are the cause of T cell exhaustion during chronic viral infection JO - Proc Natl Acad Sci U S A VL - 106 UR - https://doi.org/10.1073/pnas.0809818106 DO - 10.1073/pnas.0809818106 ID - Mueller2009 ER - TY - JOUR AU - Utzschneider, D. T. AU - Alfei, F. AU - Roelli, P. AU - Barras, D. AU - Chennupati, V. AU - Darbre, S. PY - 2016 DA - 2016// TI - High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival JO - J Exp Med VL - 213 UR - https://doi.org/10.1084/jem.20150598 DO - 10.1084/jem.20150598 ID - Utzschneider2016 ER - TY - JOUR AU - Tay, S. S. AU - Wong, Y. C. AU - McDonald, D. M. AU - Wood, N. A. AU - Roediger, B. AU - Sierro, F. PY - 2014 DA - 2014// TI - Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses JO - Proc Natl Acad Sci U S A VL - 111 UR - https://doi.org/10.1073/pnas.1406674111 DO - 10.1073/pnas.1406674111 ID - Tay2014 ER - TY - JOUR AU - Dembek, C. AU - Protzer, U. AU - Roggendorf, M. PY - 2018 DA - 2018// TI - Overcoming immune tolerance in chronic hepatitis B by therapeutic vaccination JO - Curr Opin Virol VL - 30 UR - https://doi.org/10.1016/j.coviro.2018.04.003 DO - 10.1016/j.coviro.2018.04.003 ID - Dembek2018 ER - TY - JOUR AU - Bouchard, M. J. AU - Schneider, R. J. PY - 2004 DA - 2004// TI - The enigmatic X gene of hepatitis B virus JO - J Virol VL - 78 UR - https://doi.org/10.1128/JVI.78.23.12725-12734.2004 DO - 10.1128/JVI.78.23.12725-12734.2004 ID - Bouchard2004 ER - TY - JOUR AU - Niu, C. AU - Livingston, C. M. AU - Li, L. AU - Beran, R. K. AU - Daffis, S. AU - Ramakrishnan, D. PY - 2017 DA - 2017// TI - The Smc5/6 complex restricts HBV when localized to ND10 without inducing an innate immune response and is counteracted by the HBV X protein shortly after infection JO - PLoS One VL - 12 UR - https://doi.org/10.1371/journal.pone.0169648 DO - 10.1371/journal.pone.0169648 ID - Niu2017 ER - TY - JOUR AU - King, T. H. AU - Kemmler, C. B. AU - Guo, Z. AU - Mann, D. AU - Lu, Y. AU - Coeshott, C. PY - 2014 DA - 2014// TI - A whole recombinant yeast-based therapeutic vaccine elicits HBV X, S and core specific T cells in mice and activates human T cells recognizing epitopes linked to viral clearance JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0101904 DO - 10.1371/journal.pone.0101904 ID - King2014 ER - TY - JOUR AU - Crispe, I. N. PY - 2009 DA - 2009// TI - The liver as a lymphoid organ JO - Annu Rev Immunol VL - 27 UR - https://doi.org/10.1146/annurev.immunol.021908.132629 DO - 10.1146/annurev.immunol.021908.132629 ID - Crispe2009 ER - TY - JOUR AU - Thomson, A. W. AU - Knolle, P. A. PY - 2010 DA - 2010// TI - Antigen-presenting cell function in the tolerogenic liver environment JO - Nat Rev Immunol VL - 10 UR - https://doi.org/10.1038/nri2858 DO - 10.1038/nri2858 ID - Thomson2010 ER - TY - JOUR AU - Huang, L. R. AU - Wohlleber, D. AU - Reisinger, F. AU - Jenne, C. N. AU - Cheng, R. L. AU - Abdullah, Z. PY - 2013 DA - 2013// TI - Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection JO - Nat Immunol VL - 14 UR - https://doi.org/10.1038/ni.2573 DO - 10.1038/ni.2573 ID - Huang2013 ER - TY - JOUR AU - Cebula, M. AU - Riehn, M. AU - Hillebrand, U. AU - Kratzer, R. F. AU - Kreppel, F. AU - Koutsoumpli, G. PY - 2017 DA - 2017// TI - TLR9-mediated conditioning of liver environment is essential for successful intrahepatic immunotherapy and effective memory recall JO - Mol Ther VL - 25 UR - https://doi.org/10.1016/j.ymthe.2017.06.018 DO - 10.1016/j.ymthe.2017.06.018 ID - Cebula2017 ER - TY - JOUR AU - Huang, L. R. AU - Wu, H. L. AU - Chen, P. J. AU - Chen, D. S. PY - 2006 DA - 2006// TI - An immunocompetent mouse model for the tolerance of human chronic hepatitis B virus infection JO - Proc Natl Acad Sci U S A VL - 103 UR - https://doi.org/10.1073/pnas.0608578103 DO - 10.1073/pnas.0608578103 ID - Huang2006 ER - TY - JOUR AU - Liao, C. W. AU - Chen, C. A. AU - Lee, C. N. AU - Su, Y. N. AU - Chang, M. C. AU - Syu, M. H. PY - 2005 DA - 2005// TI - Fusion protein vaccine by domains of bacterial exotoxin linked with a tumor antigen generates potent immunologic responses and antitumor effects JO - Cancer Res VL - 65 UR - https://doi.org/10.1158/0008-5472.CAN-05-0958 DO - 10.1158/0008-5472.CAN-05-0958 ID - Liao2005 ER - TY - JOUR AU - Wu, L. L. AU - Peng, W. H. AU - Wu, H. L. AU - Miaw, S. C. AU - Yeh, S. H. AU - Yang, H. C. PY - 2019 DA - 2019// TI - Lymphocyte antigen 6 complex, locus C+ monocytes and Kupffer cells orchestrate liver immune responses against hepatitis B virus in mice JO - Hepatology. VL - 69 UR - https://doi.org/10.1002/hep.30476 DO - 10.1002/hep.30476 ID - Wu2019 ER - TY - JOUR AU - Zhu, J. AU - Chen, H. AU - Huang, X. AU - Jiang, S. AU - Yang, Y. PY - 2016 DA - 2016// TI - Ly6Chi monocytes regulate T cell responses in viral hepatitis JO - JCI Insight VL - 1 ID - Zhu2016 ER - TY - JOUR AU - Zhao, H. J. AU - Han, Q. J. AU - Wang, G. AU - Lin, A. AU - Xu, D. Q. AU - Wang, Y. Q. PY - 2019 DA - 2019// TI - Poly I:C-based rHBVvac therapeutic vaccine eliminates HBV via generation of HBV-specific CD8+ effector memory T cells JO - Gut. VL - 68 UR - https://doi.org/10.1136/gutjnl-2017-315588 DO - 10.1136/gutjnl-2017-315588 ID - Zhao2019 ER - TY - JOUR AU - Lv, S. AU - Wang, J. AU - Dou, S. AU - Yang, X. AU - Ni, X. AU - Sun, R. PY - 2014 DA - 2014// TI - Nanoparticles encapsulating hepatitis B virus cytosine-phosphate-guanosine induce therapeutic immunity against HBV infection JO - Hepatology. VL - 59 UR - https://doi.org/10.1002/hep.26654 DO - 10.1002/hep.26654 ID - Lv2014 ER - TY - JOUR AU - Chou, H. H. AU - Chien, W. H. AU - Wu, L. L. AU - Cheng, C. H. AU - Chung, C. H. AU - Horng, J. H. PY - 2015 DA - 2015// TI - Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota JO - Proc Natl Acad Sci U S A VL - 112 UR - https://doi.org/10.1073/pnas.1424775112 DO - 10.1073/pnas.1424775112 ID - Chou2015 ER - TY - JOUR AU - Rai, D. AU - Pham, N. L. AU - Harty, J. T. AU - Badovinac, V. P. PY - 2009 DA - 2009// TI - Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts JO - J Immunol VL - 183 UR - https://doi.org/10.4049/jimmunol.0902874 DO - 10.4049/jimmunol.0902874 ID - Rai2009 ER - TY - JOUR AU - Lin, Y. J. AU - Wu, H. L. AU - Chen, D. S. AU - Chen, P. J. PY - 2012 DA - 2012// TI - Hepatitis B virus nucleocapsid but not free core antigen controls viral clearance in mice JO - J Virol VL - 86 UR - https://doi.org/10.1128/JVI.00608-12 DO - 10.1128/JVI.00608-12 ID - Lin2012 ER - TY - JOUR AU - Kornyeyev, D. AU - Ramakrishnan, D. AU - Voitenleitner, C. AU - Livingston, C. M. AU - Xing, W. AU - Hung, M. PY - 2019 DA - 2019// TI - Spatiotemporal analysis of hepatitis B virus X protein in primary human hepatocytes JO - J Virol VL - 93 UR - https://doi.org/10.1128/JVI.00248-19 DO - 10.1128/JVI.00248-19 ID - Kornyeyev2019 ER - TY - JOUR AU - Kosinska, A. D. AU - Moeed, A. AU - Kallin, N. AU - Festag, J. AU - Su, J. AU - Steiger, K. PY - 2019 DA - 2019// TI - Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection JO - Sci Rep VL - 9 UR - https://doi.org/10.1038/s41598-019-47149-w DO - 10.1038/s41598-019-47149-w ID - Kosinska2019 ER - TY - JOUR AU - Li, J. AU - Ge, J. AU - Ren, S. AU - Zhou, T. AU - Sun, Y. AU - Sun, H. PY - 2015 DA - 2015// TI - Hepatitis B surface antigen (HBsAg) and core antigen (HBcAg) combine CpG oligodeoxynucletides as a novel therapeutic vaccine for chronic hepatitis B infection JO - Vaccine. VL - 33 UR - https://doi.org/10.1016/j.vaccine.2015.03.079 DO - 10.1016/j.vaccine.2015.03.079 ID - Li2015 ER - TY - JOUR AU - Lee, B. O. AU - Tucker, A. AU - Frelin, L. AU - Sallberg, M. AU - Jones, J. AU - Peters, C. PY - 2009 DA - 2009// TI - Interaction of the hepatitis B core antigen and the innate immune system JO - J Immunol VL - 182 UR - https://doi.org/10.4049/jimmunol.0803683 DO - 10.4049/jimmunol.0803683 ID - Lee2009 ER - TY - JOUR AU - Sitia, G. AU - Isogawa, M. AU - Iannacone, M. AU - Campbell, I. L. AU - Chisari, F. V. AU - Guidotti, L. G. PY - 2004 DA - 2004// TI - MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs JO - J Clin Invest VL - 113 UR - https://doi.org/10.1172/JCI200421087 DO - 10.1172/JCI200421087 ID - Sitia2004 ER - TY - JOUR AU - Sitia, G. AU - Iannacone, M. AU - Aiolfi, R. AU - Isogawa, M. AU - Rooijen, N. AU - Scozzesi, C. PY - 2011 DA - 2011// TI - Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis JO - PLoS Pathog VL - 7 UR - https://doi.org/10.1371/journal.ppat.1002061 DO - 10.1371/journal.ppat.1002061 ID - Sitia2011 ER - TY - JOUR AU - Guilliams, M. AU - Mildner, A. AU - Yona, S. PY - 2018 DA - 2018// TI - Developmental and functional heterogeneity of monocytes JO - Immunity. VL - 49 UR - https://doi.org/10.1016/j.immuni.2018.10.005 DO - 10.1016/j.immuni.2018.10.005 ID - Guilliams2018 ER - TY - JOUR AU - Movita, D. AU - Garde, M. D. AU - Biesta, P. AU - Kreefft, K. AU - Haagmans, B. AU - Zuniga, E. PY - 2015 DA - 2015// TI - Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct JO - J Virol VL - 89 UR - https://doi.org/10.1128/JVI.03733-14 DO - 10.1128/JVI.03733-14 ID - Movita2015 ER - TY - JOUR AU - Koker, S. AU - Hoecke, L. AU - Beuckelaer, A. AU - Roose, K. AU - Deswarte, K. AU - Willart, M. A. PY - 2017 DA - 2017// TI - Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12 JO - Sci Rep VL - 7 UR - https://doi.org/10.1038/s41598-017-06236-6 DO - 10.1038/s41598-017-06236-6 ID - Koker2017 ER - TY - JOUR AU - Nguyen, K. B. AU - Salazar-Mather, T. P. AU - Dalod, M. Y. AU - Deusen, J. B. AU - Wei, X. Q. AU - Liew, F. Y. PY - 2002 DA - 2002// TI - Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection JO - J Immunol VL - 169 UR - https://doi.org/10.4049/jimmunol.169.8.4279 DO - 10.4049/jimmunol.169.8.4279 ID - Nguyen2002 ER - TY - JOUR AU - Bian, Y. AU - Zhang, Z. AU - Sun, Z. AU - Zhao, J. AU - Zhu, D. AU - Wang, Y. PY - 2017 DA - 2017// TI - Vaccines targeting preS1 domain overcome immune tolerance in hepatitis B virus carrier mice JO - Hepatology. VL - 66 UR - https://doi.org/10.1002/hep.29239 DO - 10.1002/hep.29239 ID - Bian2017 ER - TY - JOUR AU - Huang, L. R. AU - Gabel, Y. A. AU - Graf, S. AU - Arzberger, S. AU - Kurts, C. AU - Heikenwalder, M. PY - 2012 DA - 2012// TI - Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice JO - Gastroenterology VL - 142 UR - https://doi.org/10.1053/j.gastro.2012.03.006 DO - 10.1053/j.gastro.2012.03.006 ID - Huang2012 ER - TY - JOUR AU - Tzeng, H. T. AU - Tsai, H. F. AU - Liao, H. J. AU - Lin, Y. J. AU - Chen, L. AU - Chen, P. J. PY - 2012 DA - 2012// TI - PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0039179 DO - 10.1371/journal.pone.0039179 ID - Tzeng2012 ER -