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Table 3 Results for the significant associations between 7 genome-wide association study-identified single nucleotide polymorphisms and the risk of pancreatic cancer

From: Validation of genome-wide association study-identified single nucleotide polymorphisms in a case-control study of pancreatic cancer from Taiwan

SNPs (chromosome locus, nearest gene (s)) Cases
n (%)
Controls
n (%)
OR (95% CI)a P
rs2816938 (1q32.1, NR5A2)
 TT 232 (83.5) 583 (88.7) Reference  
 AT 44 (15.8) 72 (11.0) 1.68 (1.09–2.58) 0.02
 AA 2 (0.7) 2 (0.3) 1.58 (0.22–11.39) 0.65
 AT+AA 46 (16.6) 74 (11.3) 1.68 (1.10–2.55) 0.02
 Every 1 copy of A    1.61 (1.08–2.40) 0.02
rs10094872 (8q24.21, MYC)
 AA 159 (57.2) 429 (65.3) Reference  
 TA 111 (39.9) 196 (29.8) 1.61 (1.19–2.22) 0.002
 TT 8 (2.9) 32 (4.9) 0.62 (0.27–1.44) 0.27
 TA + TT 119 (42.8) 228 (34.7) 1.48 (1.09–2.00) 0.01
 Every 1 copy of T    1.23 (0.95–1.59) 0.11
rs9581943 (13q12.2, PDX1)
 GG 111 (40.1) 323 (49.1) Reference  
 GA 126 (45.5) 250 (38.0) 1.41 (1.03–1.94) 0.03
 AA 40 (14.4) 85 (12.9) 1.38 (0.87–2.17) 0.17
 GA + AA 166 (59.9) 335 (50.9) 1.40 (1.04–1.89) 0.03
 Every 1 copy of A    1.23 (1.00–1.52) 0.05
rs4885093 (13q22.1, intergenic region)
 AA 59 (21.2) 196 (29.8) Reference  
 AG 150 (54.0) 335 (50.9) 1.43 (0.99–2.06) 0.06
 GG 69 (24.8) 127 (19.3) 1.65 (1.07–2.54) 0.02
 AG + GG 219 (78.8) 462 (70.2) 1.49 (1.05–2.11) 0.02
 Every 1 copy of G    1.29 (1.04–1.59) 0.02
rs9573163 (13q22.1, intergenic region)
 GG 59 (21.2) 195 (29.6) Reference  
 GC 150 (54.0) 337 (51.2) 1.40 (0.97–2.02) 0.07
 CC 69 (24.8) 126 (19.2) 1.64 (1.06–2.53) 0.03
 GC + CC 219 (78.8) 463 (70.4) 1.47 (1.04–2.08) 0.03
 Every 1 copy of C    1.28 (1.03–1.59) 0.02
rs9543325 (13q22.1, intergenic region)
 TT 62 (22.3) 198 (30.1) Reference  
 TC 146 (52.5) 333 (50.7) 1.40 (0.99–1.98) 0.06
 CC 70 (25.2) 126 (19.2) 1.77 (1.18–2.67) 0.006
 TC + CC 216 (77.7) 459 (69.9) 1.44 (1.02–2.02) 0.04
 Every 1 copy of C    1.28 (1.03–1.58) 0.02
rs9573166 (13q22.1, intergenic region)
 AA 62 (22.4) 193 (29.4) Reference  
 GA 145 (52.3) 335 (51.0) 1.29 (0.90–1.86) 0.17
 GG 70 (25.3) 129 (19.6) 1.56 (1.02–2.39) 0.04
 GA + GG 215 (77.6) 464 (70.6) 1.37 (0.97–1.93) 0.08
 Every 1 copy of G    1.25 (1.01–1.55) 0.04
  1. Abbreviations: CI confidence interval, OR odds ratio
  2. aOR and 95% CI were calculated using unconditional logistic regression, adjusted for age, sex, and education