Table 3 Results for the significant associations between 7 genome-wide association study-identified single nucleotide polymorphisms and the risk of pancreatic cancer
SNPs (chromosome locus, nearest gene (s)) | Cases n (%) | Controls n (%) | OR (95% CI)a | P |
|---|---|---|---|---|
rs2816938 (1q32.1, NR5A2) | ||||
 TT | 232 (83.5) | 583 (88.7) | Reference |  |
 AT | 44 (15.8) | 72 (11.0) | 1.68 (1.09–2.58) | 0.02 |
 AA | 2 (0.7) | 2 (0.3) | 1.58 (0.22–11.39) | 0.65 |
 AT+AA | 46 (16.6) | 74 (11.3) | 1.68 (1.10–2.55) | 0.02 |
 Every 1 copy of A |  |  | 1.61 (1.08–2.40) | 0.02 |
rs10094872 (8q24.21, MYC) | ||||
 AA | 159 (57.2) | 429 (65.3) | Reference |  |
 TA | 111 (39.9) | 196 (29.8) | 1.61 (1.19–2.22) | 0.002 |
 TT | 8 (2.9) | 32 (4.9) | 0.62 (0.27–1.44) | 0.27 |
 TA + TT | 119 (42.8) | 228 (34.7) | 1.48 (1.09–2.00) | 0.01 |
 Every 1 copy of T |  |  | 1.23 (0.95–1.59) | 0.11 |
rs9581943 (13q12.2, PDX1) | ||||
 GG | 111 (40.1) | 323 (49.1) | Reference |  |
 GA | 126 (45.5) | 250 (38.0) | 1.41 (1.03–1.94) | 0.03 |
 AA | 40 (14.4) | 85 (12.9) | 1.38 (0.87–2.17) | 0.17 |
 GA + AA | 166 (59.9) | 335 (50.9) | 1.40 (1.04–1.89) | 0.03 |
 Every 1 copy of A |  |  | 1.23 (1.00–1.52) | 0.05 |
rs4885093 (13q22.1, intergenic region) | ||||
 AA | 59 (21.2) | 196 (29.8) | Reference |  |
 AG | 150 (54.0) | 335 (50.9) | 1.43 (0.99–2.06) | 0.06 |
 GG | 69 (24.8) | 127 (19.3) | 1.65 (1.07–2.54) | 0.02 |
 AG + GG | 219 (78.8) | 462 (70.2) | 1.49 (1.05–2.11) | 0.02 |
 Every 1 copy of G |  |  | 1.29 (1.04–1.59) | 0.02 |
rs9573163 (13q22.1, intergenic region) | ||||
 GG | 59 (21.2) | 195 (29.6) | Reference |  |
 GC | 150 (54.0) | 337 (51.2) | 1.40 (0.97–2.02) | 0.07 |
 CC | 69 (24.8) | 126 (19.2) | 1.64 (1.06–2.53) | 0.03 |
 GC + CC | 219 (78.8) | 463 (70.4) | 1.47 (1.04–2.08) | 0.03 |
 Every 1 copy of C |  |  | 1.28 (1.03–1.59) | 0.02 |
rs9543325 (13q22.1, intergenic region) | ||||
 TT | 62 (22.3) | 198 (30.1) | Reference |  |
 TC | 146 (52.5) | 333 (50.7) | 1.40 (0.99–1.98) | 0.06 |
 CC | 70 (25.2) | 126 (19.2) | 1.77 (1.18–2.67) | 0.006 |
 TC + CC | 216 (77.7) | 459 (69.9) | 1.44 (1.02–2.02) | 0.04 |
 Every 1 copy of C |  |  | 1.28 (1.03–1.58) | 0.02 |
rs9573166 (13q22.1, intergenic region) | ||||
 AA | 62 (22.4) | 193 (29.4) | Reference |  |
 GA | 145 (52.3) | 335 (51.0) | 1.29 (0.90–1.86) | 0.17 |
 GG | 70 (25.3) | 129 (19.6) | 1.56 (1.02–2.39) | 0.04 |
 GA + GG | 215 (77.6) | 464 (70.6) | 1.37 (0.97–1.93) | 0.08 |
 Every 1 copy of G |  |  | 1.25 (1.01–1.55) | 0.04 |