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Table 4 Multivariate analysis to assess the independent association between the four unlinked single nucleotide polymorphisms and pancreatic cancer risk

From: Validation of genome-wide association study-identified single nucleotide polymorphisms in a case-control study of pancreatic cancer from Taiwan

SNPs (chromosome locus, nearest gene (s)) Cases
n (%)
Controls
n (%)
OR (95% CI)a P
rs2816938 (1q32.1, NR5A2)
 TT 232 (83.5) 583 (88.7) Reference  
 AT+AA 46 (16.6) 74 (11.3) 1.71 (1.12–2.63) 0.01
rs10094872 (8q24.21, MYC)
 AA 159 (57.2) 429 (65.3) Reference  
 TA + TT 119 (42.8) 228 (34.7) 1.50 (1.10–2.04) 0.01
rs9581943 (13q12.2, PDX1)
 GG 111 (40.1) 323 (49.1) Reference  
 GA + AA 166 (59.9) 335 (50.9) 1.39 (1.03–1.88) 0.03
rs4885093 (13q22.1, intergenic region)
 AA 59 (21.2) 196 (29.8) Reference  
 AG + GG 219 (78.8) 462 (70.2) 1.48 (1.04–2.10) 0.03
  1. Abbreviations CI confidence interval, OR odds ratio
  2. aOR and 95% CI were calculated using multivariate unconditional logistic regression model that included, age, sex, education, and the four unlinked SNPs