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Table 2 Description of drugs used in the treatment of adults with TB based on the ATS/ CDC/ IDSA Guidelines

From: Of tuberculosis and non-tuberculous mycobacterial infections – a comparative analysis of epidemiology, diagnosis and treatment

Drug Group

Anti -TB drug

Dosage

First-linea

Isoniazid (Oral or IM or IV)

5 mg/kg (~ 300 mg)

Pyridoxine 25–50 mg/day, is given with INH to persons at risk of neuropathy

Rifampicin (Oral or IV)

10 mg/kg (~ 600 mg)

Pyrazinamide

(Oral)

1000 mg (40 - 55 kg weight)

1500 mg (56 – 75 kg weight)

2000 mg (76 – 90 kg weight)

Ethambutol

(Oral)

800 mg (40 - 55 kg weight)

1200 mg (56 – 75 kg weight)

1600 mg (76 – 90 kg weight)

Second-linea

Cycloserine (Oral)

10–15 mg/kg (usually 250–500 mg once or twice daily

Ethionamide (Oral)

10–15 mg/kg (usually 250–500 mg once or twice daily

Streptomycin (IM or IV)

15 mg/kg daily. Some clinicians prefer 25 mg/kg 3 times weekly or the 15 mg/kg dose 3 times weekly for patients with poor renal function

Amikacin/kanamycin

(IM or IV)

15 mg/kg daily. Some clinicians prefer 25 mg/kg 3 times weekly or the 15 mg/kg dose 3 times weekly for patients with poor renal function

Capreomycin (IM or IV)

15 mg/kg daily. Some clinicians prefer 25 mg/kg 3 times weekly or the 15 mg/kg dose 3 times weekly for patients with poor renal function

Para-amino salicylic acid

(Granules or tablets or IV)

200–300 mg/kg total (usually divided 100 mg/kg given 2 to 3 times daily)

Levofloxacin (Oral or IV)

500–1000 mg daily

Moxifloxacin (Oral or IV)

400 mg daily

Anti-TB drugs with limited data available on safety and effectiveness b

Bedaquiline (Oral)

400 mg daily for 14 days followed by 200 mg 3 times/wk

Linezolid (Oral or IV)

600 mg daily

Clofazimine (Oral)

100 mg daily

Delamanid (Oral)

100 mg twice daily

Meropenem (IV)

1,000 mg 3 times/day

Imipenem–cilastatin (IV)

1,000 mg 3–4 times/day

Clavulanate (Oral or IV)

250 mg 3 times/day

High-dose isoniazid (Oral or IV)

15 mg/kg daily

  1. Ref ([47]a[33]b). IM Intra-muscular; IV Intravenous. ATS American Thoracic Society; CDC Centres for Disease Control; IDSA Infectious Disease Society of America.