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Table 2 Description of drugs used in the treatment of adults with TB based on the ATS/ CDC/ IDSA Guidelines

From: Of tuberculosis and non-tuberculous mycobacterial infections – a comparative analysis of epidemiology, diagnosis and treatment

Drug Group Anti -TB drug Dosage
First-linea Isoniazid (Oral or IM or IV) 5 mg/kg (~ 300 mg)
Pyridoxine 25–50 mg/day, is given with INH to persons at risk of neuropathy
Rifampicin (Oral or IV) 10 mg/kg (~ 600 mg)
Pyrazinamide
(Oral)
1000 mg (40 - 55 kg weight)
1500 mg (56 – 75 kg weight)
2000 mg (76 – 90 kg weight)
Ethambutol
(Oral)
800 mg (40 - 55 kg weight)
1200 mg (56 – 75 kg weight)
1600 mg (76 – 90 kg weight)
Second-linea Cycloserine (Oral) 10–15 mg/kg (usually 250–500 mg once or twice daily
Ethionamide (Oral) 10–15 mg/kg (usually 250–500 mg once or twice daily
Streptomycin (IM or IV) 15 mg/kg daily. Some clinicians prefer 25 mg/kg 3 times weekly or the 15 mg/kg dose 3 times weekly for patients with poor renal function
Amikacin/kanamycin
(IM or IV)
15 mg/kg daily. Some clinicians prefer 25 mg/kg 3 times weekly or the 15 mg/kg dose 3 times weekly for patients with poor renal function
Capreomycin (IM or IV) 15 mg/kg daily. Some clinicians prefer 25 mg/kg 3 times weekly or the 15 mg/kg dose 3 times weekly for patients with poor renal function
Para-amino salicylic acid
(Granules or tablets or IV)
200–300 mg/kg total (usually divided 100 mg/kg given 2 to 3 times daily)
Levofloxacin (Oral or IV) 500–1000 mg daily
Moxifloxacin (Oral or IV) 400 mg daily
Anti-TB drugs with limited data available on safety and effectiveness b Bedaquiline (Oral) 400 mg daily for 14 days followed by 200 mg 3 times/wk
Linezolid (Oral or IV) 600 mg daily
Clofazimine (Oral) 100 mg daily
Delamanid (Oral) 100 mg twice daily
Meropenem (IV) 1,000 mg 3 times/day
Imipenem–cilastatin (IV) 1,000 mg 3–4 times/day
Clavulanate (Oral or IV) 250 mg 3 times/day
High-dose isoniazid (Oral or IV) 15 mg/kg daily
  1. Ref ([47]a[33]b). IM Intra-muscular; IV Intravenous. ATS American Thoracic Society; CDC Centres for Disease Control; IDSA Infectious Disease Society of America.