Drug Group | Anti -TB drug | Dosage |
---|---|---|
First-linea | Isoniazid (Oral or IM or IV) | 5 mg/kg (~ 300 mg) Pyridoxine 25–50 mg/day, is given with INH to persons at risk of neuropathy |
Rifampicin (Oral or IV) | 10 mg/kg (~ 600 mg) | |
Pyrazinamide (Oral) | 1000 mg (40 - 55 kg weight) 1500 mg (56 – 75 kg weight) 2000 mg (76 – 90 kg weight) | |
Ethambutol (Oral) | 800 mg (40 - 55 kg weight) 1200 mg (56 – 75 kg weight) 1600 mg (76 – 90 kg weight) | |
Second-linea | Cycloserine (Oral) | 10–15 mg/kg (usually 250–500 mg once or twice daily |
Ethionamide (Oral) | 10–15 mg/kg (usually 250–500 mg once or twice daily | |
Streptomycin (IM or IV) | 15 mg/kg daily. Some clinicians prefer 25 mg/kg 3 times weekly or the 15 mg/kg dose 3 times weekly for patients with poor renal function | |
Amikacin/kanamycin (IM or IV) | 15 mg/kg daily. Some clinicians prefer 25 mg/kg 3 times weekly or the 15 mg/kg dose 3 times weekly for patients with poor renal function | |
Capreomycin (IM or IV) | 15 mg/kg daily. Some clinicians prefer 25 mg/kg 3 times weekly or the 15 mg/kg dose 3 times weekly for patients with poor renal function | |
Para-amino salicylic acid (Granules or tablets or IV) | 200–300 mg/kg total (usually divided 100 mg/kg given 2 to 3 times daily) | |
Levofloxacin (Oral or IV) | 500–1000 mg daily | |
Moxifloxacin (Oral or IV) | 400 mg daily | |
Anti-TB drugs with limited data available on safety and effectiveness b | Bedaquiline (Oral) | 400 mg daily for 14 days followed by 200 mg 3 times/wk |
Linezolid (Oral or IV) | 600 mg daily | |
Clofazimine (Oral) | 100 mg daily | |
Delamanid (Oral) | 100 mg twice daily | |
Meropenem (IV) | 1,000 mg 3 times/day | |
Imipenem–cilastatin (IV) | 1,000 mg 3–4 times/day | |
Clavulanate (Oral or IV) | 250 mg 3 times/day | |
High-dose isoniazid (Oral or IV) | 15 mg/kg daily |