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Fig. 3 | Journal of Biomedical Science

Fig. 3

From: ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer

Fig. 3

ZNF322A-mediated biological processes in A549 lung cancer cells. a Differentially regulated proteins from proteome and phosphoproteome profiles (normalized ratio ≥ 1.5 or ≤ 0.67) were annotated with GO terms. Each node represents an enriched GO term (corrected p-value < 0.05), and the size of nodes represents the total number of genes in each GO term. Pie chart in a node represents the proportion of significantly regulated proteins derived from proteomics and phosphoprotemics (red: protein expression; orange: protein phosphorylation). The edge represents gene overlap score between nodes over a given threshold (0.5). Functionally related GO terms are manually grouped and labeled. b Pathway analysis of ZNF322A-regulated phosphoproteins. Top 15 enriched pathways of the phosphoproteomics with the lowest p-value. The number of entities is shown as bar label

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