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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Hepatitis C virus vaccine design: focus on the humoral immune response

Fig. 1

Hepatitis C E1 and E2 glycoprotein structures. a Linear diagram of HCV E1 (aa192–383) and crystal structures of E1 segments aa192–271 (PDB: 4UOI) and aa314–324 (PDB: 4N0Y). b Linear diagram of HCV E2 (aa384–746) and ribbon representation of the E2 crystal structure (PDB: 4MWF). E2 is divided into the following structural components: three hypervariable regions (HVR1, HVR2 and igVR), a front layer, two β-sandwich regions, CD81 binding loop, a back layer followed by the stem region and transmembrane (TM) domain. The neutralizing face with epitopes I (orange), II (violet) and III (blue) is indicated. a-b N-linked glycosylation sites as tree-like representations and well-defined regions containing α-helices and β-sheets are shown in the linear diagram and X-ray crystallographic structure of both glycoproteins, respectively

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