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Fig. 2 | Journal of Biomedical Science

Fig. 2

From: Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes

Fig. 2

Consensus model of amino acid-dependent mTORC1 activation at the lysosome. Leucine (Leu), arginine (Arg), and S-adenosylmethionine (SAM) are sensed by cytosolic and lysosomal sensors (SESN2, LRS, CASTOR1, SLC38A9, and SAMTOR). These signals converge on Rag GTPases (heterodimeric RagA/B-RagC/D GTPases), which recruit mTORC1 onto the lysosomal surface. There mTORC1 is activated by association with the Rheb GTPase. The efflux of leucine from the lysosomal lumen to the cytosol through arginine-sensitive SLC38A9 also activates mTORC1 via cytosolic sensors

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