Table 1 List of genes at the hotspot regions of iPSC-specific CNVs
iPSCs (n = 82) | Control (n = 1093) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Chr | Start | End | Locus | Duplication | Deletion | Duplication | Deletion | P value | Genes Contained |
4 | 62690392 | 62945462 | q13.1 | 5 | 0 | 1 | 0 | < 0.0001 | ADGRL3, ADGRL3-AS1 |
4 | 92930866 | 94220988 | q22.1–q22–2 | 38 | 2 | 0 | 1 | < 0.0001 | GRID2, LNCPRESS2 |
5 | 147202104 | 147449067 | q32 | 8 | 0 | 0 | 0 | < 0.0001 | SPINK5, SPINK1, SCGB3A2, C5orf46 |
6 | 94291842 | 94849832 | q16.1 | 22 | 0 | 0 | 0 | < 0.0001 | TSG1 |
7 | 121549706 | 122245008 | q31.32 | 12 | 0 | 1 | 0 | < 0.0001 | PTPRZ1, CADPS2, AASS, FEZF1-AS1, FEZF1 |
10 | 54932474 | 55398702 | q21.1 | 6 | 0 | 0 | 0 | < 0.0001 | NA |
13 | 55695571 | 56471149 | q21.1 | 15 | 0 | 0 | 2 | < 0.0001 | MIR5007 |
20 | 29620219 | 31558271 | q11.21 | 5 | 0 | 0 | 0 | < 0.0001 | MYLK2, EFCAB8, BCL2L1, HM13, FRG1BP, FRG1DP, DEFB122, COMMD7, POFUT1, NOL4L, HCK, PDRG1, NOL4L-DT, MLLT10P1, DEFB115, DEFB116, DEFB119, DEFB118, DEFB121, DEFB124, DEFB123, LINC00028, REM1, ID1, HM13-AS1, MIR3193, COX4I2, TPX2, ABALON, DUSP15, FOXS1, TTLL9, MIR7641–2, CCM2L, XKR7, PLAGL2, TM9SF4, TSPY26P, KIF3B, MIR1825, ASXL1, LOC101929698, C20orf203, DNMT3B, MAPRE1 |
X | 112880475 | 113795367 | q23 | 27 | 0 | 0 | 0 | < 0.0001 | XACT |
X | 114766295 | 114897324 | q23 | 8 | 0 | 0 | 0 | < 0.0001 | PLS3,PLS3-AS1 |