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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: Dissecting the conformation of glycans and their interactions with proteins

Fig. 5

Mechanism of proangiogenic activity resulting from the binding of GHCer to TRAX. a Complex model of GHCer and TRAX predicted with molecular docking software in a previous study [9]; only one H-bond could be formed between GHCer and TRAX in this prediction. b GHCer-TRAX model predicted using the strategy of molecular dynamics simulation with a low-energy conformer of GHCer. GHCer formed as many as seven H-bonds interacting with E216, Q223, Q219, S141 and L142 on TRAX. c GHCer interacts with TRAX specifically, competing with PLCb1 and, thus, inducing calcium mobilization and angiogenesis in endothelial cells

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