Fig. 4
From: SUMO proteins in the cardiovascular system: friend or foe?
Participation of SUMOylation in molecular signalling pathways involved in dilated cardiomyopathy. SUMO plays a friendly role upon conjugating with Drp1 to inhibit mitochondrial disfunction and binding to Lamin A for its proper localization, but has a harmful effect when binding to CAST and Capn to induce apoptosis. Capn2 calpain small subunit 2, CAST calpastatin, Drp1 dynamin related protein 1, SENP sentrin/SUMO-specific proteases