Skip to main content
Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Granulocyte-colony stimulating factor gene therapy as a novel therapeutics for stroke in a mouse model

Fig. 4

Effect of hG-CSF gene therapy on endoplasmic reticulum stress. GRP78/BiP is an ER chaperone molecule as well as an ER intraluminal stress sensor, while the CHOP is a molecular hallmark of ER stress. a, b Western blot analysis of GRP78 in the frontal and middle brain sections of sham, AAV-CMV-GFP and AAV-CMV-hG-CSF treated mice at a 4- and b 7-days post-BCAO. c, d Similarly, western blot analysis of CHOP at c 4- and d 7-days. Statistical analysis was performed by One Way ANOVA, with Tukey as post hoc test and expressed as means ± S.E.M; *p < 0.05/**p < 0.01/***p < 0.001 versus Sham group while #p < 0.05/##p < 0.01/###p < 0.001 versus AAV-CMV-GFP- treated group (n = 6 animals/group)

Back to article page