Skip to main content

Table 2 Immunological parameters in mothers according to rs1808212 PPARG genotypes along pregnancy

From: Association study of rs1801282 PPARG gene polymorphism and immune cells and cytokine levels in a Spanish pregnant women cohort and their offspring

Immunological parameters 24 Weeks p 34 Weeks p 40 Weeks p
Pro12Pro (CC)
n = 87
Pro12Ala (CG)
n = 15
Pro12Pro (CC)
n = 115
Pro12Ala (CG)
n = 19
Pro12Pro (CC)
n = 91
Pro12Ala (CG)
n = 16
Leukocytes (103/µl) 10.68 (10.11–11.24) 9.41 (7.95–10.87) 0.09 10.36 (9.93–10.79) 9.12 (8.23–10.01) 0.028 13.44 (12.51–14.36) 14.38 (12.13–16.63) 0.43
Neutrophils (103/µl) 7.98 (7.50–8.46) 6.99 (5.78–8.20) 0.12 7.68 (7.32–8.03) 6.65 (5.83–7.48) 0.031 11.22 (10.32–12.11) 12.03 (9.85–14.22) 0.48
Monocytes (103/µl) 0.50 (0.47–0.54) 0.48 (0.40–0.56) 0.63 0.55 (0.52–0.58) 0.49 (0.44–0.55) 0.18 0.54 (0.49–0.58) 0.55 (0.44–0.65) 0.85
Eosinophils (103/µl) 0.20 (0.17–0.23) 0.18 (0.14–0.22) 0.66 0.16 (0.14–0.18) 0.16 (0.12–0.19) 0.97 0.11 (0.09–0.13) 0.13 (0.09–0.16) 0.60
Basophils (103/µl) 0.04 (0.034–0.047) 0.05 (0.035–0.073) 0.12 0.044 (0.040–0.049) 0.053 (0.038–0.067) 0.13 0.044 (0.037–0.050) 0.055 (0.040–0.051) 0.16
Lymphocytes (103/µl) 1.83 (1.72–1.93) 1.61 (1.34–1.89) 0.12 1.79 (1.70–1.88) 1.62 (1.42–1.83) 0.18 1.39 (1.25–1.53) 1.48 (1.13–1.82) 0.64
CD3 (103/µl) 1.34 (1.26–1.42) 1.20 (0.98–1.42) 0.17 1.33 (1.27–1.40) 1.24 (1.07–1.41) 0.29 1.01 (0.89–1.26) 0.84 (0.60–1.08) 0.31
CD4 (103/µl) 0.87 (0.82–0.92) 0.77 (0.64–0.91) 0.18 0.86 (0.81–0.90) 0.79 (0.68–0.89) 0.22 0.64 (0.55–0.72) 0.51 (0.33–0.68) 0.26
CD8 (103/µl) 0.47 (0.44–0.51) 0.47 (0.37–0.57) 0.91 0.47 (0.44–0.51) 0.48 (0.40–0.57) 0.87 0.37 (0.32–0.42) 0.38 (0.22–0.55) 0.81
CD19 (103/µl) 0.18 (0.16–0.20) 0.14 (0.15–0.18) 0.08 0.17 (0.15–0.18) 0.13 (0.09–0.16) 0.09 0.12 (0.10–0.14) 0.08 (0.06–0.09)  < 0.001
CD4/CD8 ratio 1.98 (1.84–2.12) 1.71 (1.53–1.90) 0.023 1.95 (1.82–2.08) 1.70 (1.51–1.90) 0.032 1.93 (1.75–2.11) 1.51 (1.10–1.91 0.09
NK (103/µl) 0.16 (0.14–0.18) 0.12 (0.85–0.16) 0.11 0.13 (0.12–0.14) 0.11 (0.08–0.14) 0.14 0.14 (0.12–0.16) 0.14 (0.07–0.21) 0.99
LUC (%) 1.31 (1.19–1.44) 1.13 (0.86–1.40 0.25 1.55 (1.40–1.70) 1.74 (1.37–2.11) 0.34 1.22 (1.07–1.37) 1.04 (0.79–1.30) 0.32
IL-6 (pg/mL) 45.50 (21.40–69.60) 29.17 (3.66–54.68) 0.56 62.81 (16.45–109.16) 44.14 (2.72–85.56) 0.72 114.39 (52.90–175.88) 61.43 (16.66–106.19) 0.46
IL-10 (pg/mL) 71.47 (13.72–129.22) 52.39 (− 1.78–106.57) 0.78 58.06 (29.30–86.32) 222.52 (− 77.39–522.44) 0.24 161.57 (78.57–244.58) 116.71 (− 40.49–223.92) 0.63
TNF (pg/mL) 13.44 (7.86–19.02) 23.54 (2.44–44.63) 0.17 18.36 (12.29–24.43) 18.93 (− 50.27–88.12) 0.96 16.66 (9.16–24.16) 21.25 (2.83–39.67) 0.58
  1. Results are expressed as mean (95% confidence interval). Bold: P-value < 0.05. NK natural killer cells, LUC large unstained cells, IL interleukin