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Table 2 Immunological parameters in mothers according to rs1808212 PPARG genotypes along pregnancy

From: Association study of rs1801282 PPARG gene polymorphism and immune cells and cytokine levels in a Spanish pregnant women cohort and their offspring

Immunological parameters

24 Weeks

p

34 Weeks

p

40 Weeks

p

Pro12Pro (CC)

n = 87

Pro12Ala (CG)

n = 15

Pro12Pro (CC)

n = 115

Pro12Ala (CG)

n = 19

Pro12Pro (CC)

n = 91

Pro12Ala (CG)

n = 16

Leukocytes (103/µl)

10.68 (10.11–11.24)

9.41 (7.95–10.87)

0.09

10.36 (9.93–10.79)

9.12 (8.23–10.01)

0.028

13.44 (12.51–14.36)

14.38 (12.13–16.63)

0.43

Neutrophils (103/µl)

7.98 (7.50–8.46)

6.99 (5.78–8.20)

0.12

7.68 (7.32–8.03)

6.65 (5.83–7.48)

0.031

11.22 (10.32–12.11)

12.03 (9.85–14.22)

0.48

Monocytes (103/µl)

0.50 (0.47–0.54)

0.48 (0.40–0.56)

0.63

0.55 (0.52–0.58)

0.49 (0.44–0.55)

0.18

0.54 (0.49–0.58)

0.55 (0.44–0.65)

0.85

Eosinophils (103/µl)

0.20 (0.17–0.23)

0.18 (0.14–0.22)

0.66

0.16 (0.14–0.18)

0.16 (0.12–0.19)

0.97

0.11 (0.09–0.13)

0.13 (0.09–0.16)

0.60

Basophils (103/µl)

0.04 (0.034–0.047)

0.05 (0.035–0.073)

0.12

0.044 (0.040–0.049)

0.053 (0.038–0.067)

0.13

0.044 (0.037–0.050)

0.055 (0.040–0.051)

0.16

Lymphocytes (103/µl)

1.83 (1.72–1.93)

1.61 (1.34–1.89)

0.12

1.79 (1.70–1.88)

1.62 (1.42–1.83)

0.18

1.39 (1.25–1.53)

1.48 (1.13–1.82)

0.64

CD3 (103/µl)

1.34 (1.26–1.42)

1.20 (0.98–1.42)

0.17

1.33 (1.27–1.40)

1.24 (1.07–1.41)

0.29

1.01 (0.89–1.26)

0.84 (0.60–1.08)

0.31

CD4 (103/µl)

0.87 (0.82–0.92)

0.77 (0.64–0.91)

0.18

0.86 (0.81–0.90)

0.79 (0.68–0.89)

0.22

0.64 (0.55–0.72)

0.51 (0.33–0.68)

0.26

CD8 (103/µl)

0.47 (0.44–0.51)

0.47 (0.37–0.57)

0.91

0.47 (0.44–0.51)

0.48 (0.40–0.57)

0.87

0.37 (0.32–0.42)

0.38 (0.22–0.55)

0.81

CD19 (103/µl)

0.18 (0.16–0.20)

0.14 (0.15–0.18)

0.08

0.17 (0.15–0.18)

0.13 (0.09–0.16)

0.09

0.12 (0.10–0.14)

0.08 (0.06–0.09)

 < 0.001

CD4/CD8 ratio

1.98 (1.84–2.12)

1.71 (1.53–1.90)

0.023

1.95 (1.82–2.08)

1.70 (1.51–1.90)

0.032

1.93 (1.75–2.11)

1.51 (1.10–1.91

0.09

NK (103/µl)

0.16 (0.14–0.18)

0.12 (0.85–0.16)

0.11

0.13 (0.12–0.14)

0.11 (0.08–0.14)

0.14

0.14 (0.12–0.16)

0.14 (0.07–0.21)

0.99

LUC (%)

1.31 (1.19–1.44)

1.13 (0.86–1.40

0.25

1.55 (1.40–1.70)

1.74 (1.37–2.11)

0.34

1.22 (1.07–1.37)

1.04 (0.79–1.30)

0.32

IL-6 (pg/mL)

45.50 (21.40–69.60)

29.17 (3.66–54.68)

0.56

62.81 (16.45–109.16)

44.14 (2.72–85.56)

0.72

114.39 (52.90–175.88)

61.43 (16.66–106.19)

0.46

IL-10 (pg/mL)

71.47 (13.72–129.22)

52.39 (− 1.78–106.57)

0.78

58.06 (29.30–86.32)

222.52 (− 77.39–522.44)

0.24

161.57 (78.57–244.58)

116.71 (− 40.49–223.92)

0.63

TNF (pg/mL)

13.44 (7.86–19.02)

23.54 (2.44–44.63)

0.17

18.36 (12.29–24.43)

18.93 (− 50.27–88.12)

0.96

16.66 (9.16–24.16)

21.25 (2.83–39.67)

0.58

  1. Results are expressed as mean (95% confidence interval). Bold: P-value < 0.05. NK natural killer cells, LUC large unstained cells, IL interleukin
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Journal of Biomedical Science

ISSN: 1423-0127