Fig. 10From: KLHL17/Actinfilin, a brain-specific gene associated with infantile spasms and autism, regulates dendritic spine enlargementKLHL17/AF is critical for enlargement and maintenance of dendritic spines. Using a miRNA-based knockdown approach, klhl17 knockout mice, and expression of truncated mutants, we show that KLHL17/AF deficiency impairs spinogenesis, functional synapse formation and F-actin remodelingBack to article page