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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation

Fig. 1

Siglec-E deficiency promotes foam cells and necrotic core in atherosclerotic lesion in apoE−/− mice. ApoE−/− and apoE−/−/SE−/− mice were placed on HFD for 3 months. Heart and aortic tissues were harvested (ad). a The representative images of oil-red dye (ORD) stained aortic tissues. b The percentages of ORD stained areas in both groups of mice were quantified. c The representative images of Trichrome stained aortic root sections of male mice. d The lesion sizes and the percentages of lipid cores in the aortic roots were quantified. e Peritoneal macrophages isolated from HFD-fed apoE−/− and apoE−/−/SE−/− mice were examined by ORD staining. f The mRNA expression levels of indicated cytokines in macrophages were examined by quantitative RT-PCR

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