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Fig. 8 | Journal of Biomedical Science

Fig. 8

From: O6-methylguanine-DNA methyltransferase modulates cisplatin-induced DNA double-strand breaks by targeting the homologous recombination pathway in nasopharyngeal carcinoma

Fig. 8

Schematic illustrating the role of MGMT in HR signaling in NPC cells. After the formation of platinum–DNA adducts, MGMT is involved in RAD51 and p-BRCA1 (ser 988) expression in HR signaling pathway. Through the participation in HR activation, MGMT could modulate CDDP and PARP inhibitor sensitivity in NPC cells

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