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Table 1 IC50 values of olaparib in NPC cells

From: O6-methylguanine-DNA methyltransferase modulates cisplatin-induced DNA double-strand breaks by targeting the homologous recombination pathway in nasopharyngeal carcinoma

  HONE-1 (µM) TW01 (µM)
Control 10.5 ± 0.5 122.2 ± 8.2
O6BG 5.2 ± 0.4 61.5 ± 10.8
  1. IC50 values of olaparib were determined using a cell viability assay. Cells in the exponential phase were first treated with O6BG (120 µM) for 8 h. After medium removal and cell washing, serial concentrations of olaparib were added for three generation times. Values are presented as means ± SDs of at least three independent experiments