O6-methylguanine-DNA methyltransferase modulates cisplatin-induced DNA double-strand breaks by targeting the homologous recombination pathway in nasopharyngeal carcinoma

Table 1 IC₅₀ values of olaparib in NPC cells

	HONE-1 (µM)	TW01 (µM)
Control	10.5 ± 0.5	122.2 ± 8.2
O6BG	5.2 ± 0.4	61.5 ± 10.8

IC₅₀ values of olaparib were determined using a cell viability assay. Cells in the exponential phase were first treated with O6BG (120 µM) for 8 h. After medium removal and cell washing, serial concentrations of olaparib were added for three generation times. Values are presented as means ± SDs of at least three independent experiments

ISSN: 1423-0127