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Table 3 Statistically significant differential gene expressions associated with carbon metabolism in acetate-grown C. glabrata (q value < 0.05)

From: Transcriptomic and proteomic profiling revealed reprogramming of carbon metabolism in acetate-grown human pathogen Candida glabrata

Systematic name Genes Description Fold change (log2)
Up-regulated genes associated with carbon metabolism in acetate-grown C. glabrata
 CAGL0H04939G FBP1 Fructose 1,6-bisphosphatase 7.35
 CAGL0H06633G PCK1 Phosphoenolpyruvate carboxykinase 5.64
 CAGL0J03058G ICL1 Isocitrate lyase 4.58
 CAGL0C03223G SDH2 Succinate dehydrogenase 4.16
 CAGL0M06963G SOL2 Suppressor of Los1-1 2.68
 CAGL0L03982G MLS1 Malate synthase 2.56
 CAGL0G08712G KGD1 α-Ketoglutarate dehydrogenase complex 2.51
 CAGL0H03993G CIT1 Citrate synthase 2.11
 CAGL0F05863G SDH4 Succinate dehydrogenase 1.98
 CAGL0J00847G SDH1 Succinate dehydrogenase 1.92
 CAGL0L03740G RKI1 Ribose-5-phosphate isomerase 1.92
 CAGL0B04917G IDP2 Isocitrate dehydrogenase 1.89
 CAGL0E01287G KGD2 α-Ketoglutarate dehydrogenase complex 1.73
 CAGL0D06424G ACO1 Putative aconitate hydratase 1.63
 CAGL0K10868G CTA1 Putative catalase A 1.60
Down-regulated genes associated with carbon metabolism in acetate-grown C. glabrata
 CAGL0K00825G SER2 Phosphoserine phosphatase − 3.52
 CAGL0I09284G SHM1 Glycine hydroxymethyltransferase − 3.42
 CAGL0K06787G PYC2 Pyruvate carboxylase − 3.37
 CAGL0L11088G YOR283W Phosphatase − 3.25
 CAGL0M12034G CDC19 Pyruvate kinase − 3.18
 CAGL0J00451G TDH3 Glyceraldehyde-3-phosphate dehydrogenase − 3.15
 CAGL0K08580G AAT1 Aspartate aminotransferase − 3.11
 CAGL0F08041G PFK1 Phosphofructokinase − 3.08
 CAGL0H05137G ALD5 Aldehyde dehydrogenase − 2.90
 CAGL0L10758G PFK2 6-Phosphofructokinase − 2.73
 CAGL0I05126G ILV1 l-Threonine ammonia-lyase − 2.56
 CAGL0I05500G PRS2 Ribose phosphate diphosphokinase − 2.28
 CAGL0C05181G PRS5 Ribose phosphate diphosphokinase − 2.29
 CAGL0E06358G GPM1 Phosphoglycerate mutase − 2.24
 CAGL0I02486G ENO1 Enolase − 2.09
 CAGL0H08327G TPI1 Triose-phosphate isomerase − 2.07
 CAGL0D06402G MET15 O-Acetyl homoserine sulfhydrylase − 2.05
 CAGL0L07722G PGK1 3-Phosphoglycerate kinase − 2.03
 CAGL0L03311G SHB17 Sedoheptulose-bisphosphatase − 2.01
 CAGL0D04356G GCV1 Glycine dehydrogenase − 1.96
 CAGL0F01749G SHM2 Serine hydroxymethyltransferase − 1.94
 CAGL0H07579G HXK2 Hexokinase − 1.84
 CAGL0J01441G ADH2 Alcohol dehydrogenase − 1.55
 CAGL0J09504G MET12 Methylenetetrahydrofolate reductase − 1.51
  1. Data of differential gene expressions (q value < 0.05) was obtained from RNA-sequencing analysis. Fold change (log2) was calculated based on the gene expression of acetate-grown C. glabrata to glucose-grown C. glabrata (control)
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Journal of Biomedical Science

ISSN: 1423-0127