TY - JOUR AU - Kuo, Ming-Wei AU - Tsai, Hsiu-Hui AU - Wang, Sheng-Hung AU - Chen, Yi-Yin AU - Yu, Alice L. AU - Yu, John PY - 2021 DA - 2021/01/11 TI - Yulink, predicted from evolutionary analysis, is involved in cardiac function JO - Journal of Biomedical Science SP - 7 VL - 28 IS - 1 AB - The comparative evolutionary genomics analysis was used to study the functions of novel Ka/Ks-predicted human exons in a zebrafish model. The Yulink (MIOS, Entrez Gene: 54,468), a conserved gene from zebrafish to human with WD40 repeats at N-terminus, was identified and found to encode an 875 amino acid in human. The biological function of this Yulink gene in cardiomyocytes remains unexplored. The purpose of this study is to determine the involvement of Yulink in the functions of cardiomyocytes and to investigate its molecular regulatory mechanism. SN - 1423-0127 UR - https://doi.org/10.1186/s12929-020-00701-7 DO - 10.1186/s12929-020-00701-7 ID - Kuo2021 ER -