Fig. 3

FKBP10 related molecules and signaling pathways. a Pathway analysis of the differentially phosphoproteins and unphosphoproteins in FKBP10 siRNA LN229 compared with control cells. b The expression level of AKT, CREB and their phosphoproteins in parental, scramble, siRNAs groups of U118MG and LN229 cells. c, d PCNA protein expression level in FKBP10 knockdown and non-silencing cells with or without incubating with proteasome inhibitor MG132. e PCNA mRNA levels were analyzed using real-time RT-PCR. f–h The reduced p-AKT, p-CREB, PCNA expression and proliferation ability were restored in FKBP10 knocdown glioma cells through incubating with AKT activator SC79. The data are represented as means ± SD. *P < 0.05, **P < 0.01, ***P < 0.001