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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Modulation of human platelet activation and in vivo vascular thrombosis by columbianadin: regulation by integrin αIIbβ3 inside-out but not outside-in signals

Fig. 4

Effect of columbianadin (CBN) on ERK1/2, JNK1/2, and p38 MAPK phosphorylation in collagen-activated platelets. Washed platelets were preincubated with a solvent control (0.1% DMSO) or CBN (60 and 80 μM) and subsequently treated with collagen (1 μg/mL) for immunoblotting the (a) ERK1/2, (b) JNK1/2, and (c) p38 MAPK phosphorylation. Data are presented as the means ± SEM (n = 4). **p < 0.01 and ***p < 0.001, compared with the resting platelets; ##p < 0.01 and ###p < 0.001, compared with the 0.1% DMSO-treated group

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