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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Effects of neural stem cell transplantation in Alzheimer’s disease models

Fig. 1

The mechanisms of the respective drugs. Acetylcholinesterase inhibitors (galantamine, rivastigmine and donepezil) enhance the activity of neuro-message transduction by preventing acetylcholine degradation (1,2,3). NMDA receptor antagonists (memantine) compete with glutamate in binding to the NMDA receptor to inhibit Ca2+ influx into the postsynapse (4,5). These drugs have little effect on amyloid-beta production and aggregation, synaptogenesis, and neurogenesis yet they rescue cognitive impairment

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