Table 2 Summary of factors and effects after neural stem cell transplantation in Tg2576
From: Effects of neural stem cell transplantation in Alzheimer’s disease models
NSC | Region | Factor | Effect | Not-shown | Aβ/tau | Ref |
|---|---|---|---|---|---|---|
Tg 2576 mice | ||||||
hNSCs | Hippocampal DG | ↑α7 nAChR-expressing astrocytes | ↑Endogenous neurogenesis | ・level of Neurotrophic factor ・Synaptic density | × | [50] |
Feral cerebral cortex of pregnant C57BL/6 mice | Hippocampal DG | ↓β-secretase ↑Neprilysin | ↓Aβ production ↓phosphorylated-tau ↑Aβ clearance ↓ pro-inflammatory cytokine ↓inflammatory microglial activation ↑anti-inflammatory cytokines, ↑endogenous neurogenesis ↑synapse formation | ・The link between microglia and NSC ・level of BDNF | 〇 | [51] |