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Table 4 Summary of factors and effects after neural stem cell transplantation in 5xfAD (long-term/about 5 month)

From: Effects of neural stem cell transplantation in Alzheimer’s disease models

NSCRegionFactorEffectNot-shownAβ/tauRef
5xfAD mice (Long-term/about 5 month)
 hCNS-SCsHippocampushCNS-SCsNo change in synaptic density
No differentiated neuron
No change BDNF
No behavior improvement
・Inflammatory factors
・Neurogenesis
×[63]
 iNPCsHippocampal DGhCNS-SCs↑synaptic density
↑ Neuron
↑ BNDF
Behavior improvement
・Inflammatory factors
・Effect of respective cell type after neural cell restore.
・Neurogenesis
[64]
  1. Key: 〇 changes, not mentioned, × unchanged