Table 4 Summary of factors and effects after neural stem cell transplantation in 5xfAD (long-term/about 5 month)
From: Effects of neural stem cell transplantation in Alzheimer’s disease models
NSC | Region | Factor | Effect | Not-shown | Aβ/tau | Ref |
|---|---|---|---|---|---|---|
5xfAD mice (Long-term/about 5 month) | ||||||
hCNS-SCs | Hippocampus | hCNS-SCs | No change in synaptic density No differentiated neuron No change BDNF No behavior improvement | ・Inflammatory factors ・Neurogenesis | × | [63] |
iNPCs | Hippocampal DG | hCNS-SCs | ↑synaptic density ↑ Neuron ↑ BNDF Behavior improvement | ・Inflammatory factors ・Effect of respective cell type after neural cell restore. ・Neurogenesis | 〇 | [64] |