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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration

Fig. 4

Sympathetic nerves relay external light signals to HFSCs. Sympathetic nerves are a gateway for the communication between internal HFSC niche and external environment. Intense light irradiation to eyes promotes HFSC activation through an ipRGC-SCN-sympathetic nervous circuit. Increased norepinephrine release from cutaneous sympathetic nerves facilitates HFSC activation by upregulating hedgehog signaling

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