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Table 2 Status of different Smac mimetics

From: Anti-apoptotic proteins in the autophagic world: an update on functions of XIAP, Survivin, and BRUCE

NameClinicalTrials.gov IdentifierPhaseCondition or disease (in patients)
AZD5582Pre-clinical
APG-1387
(SM-1387)
NCT03386526Phase IAdvanced Solid Tumors or Hematologic Malignancies
NCT03585322Phase IChronic Hepatitis B
ASTX660NCT04155580Phase IRelapsed/Refractory Acute Myeloid Leukemia
NCT02503423Phase I/IIAdvanced Solid Tumors and Lymphomas
Birinapant
(TL32711)
NCT02587962Phase I/IISolid Tumors
NCT00993239Phase I
(Completed)
Refractory Solid Tumors or Lymphoma
NCT01188499Phase I
(Completed)
Advanced or Metastatic Solid Tumors
NCT01940172Phase I
(Completed)
Relapsed Ovarian Cancer
NCT01573780Phase I
(Terminated – safety unrelated issue)
Advanced Solid Tumors
NCT01681368Phase II
(Terminated – lack of a clinical benefit)
Advanced Ovarian, Fallopian Tube, and Peritoneal Cancer
Debio 1143
(AT-406, SM-406)
NCT04122625Phase ISolid Tumor
NCT03270176Phase IAdvanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) After Platinum-Based Therapy
NCT03871959Phase IPancreatic and Colorectal Advanced/Metastatic Adenocarcinoma
NCT02022098Phase I/IISquamous Cell Carcinoma of the Head and Neck
NCT01078649Phase I
(Completed)
Advanced Solid Tumors and Lymphomas
GDC-0152NCT00977067Phase I
(Terminated – safety unrelated issue)
Locally Advanced or Metastatic Malignancies
LCL161NCT02649673Phase IRelapsed/Refractory Small Cell Lung Cancer (SCLC) and Select Gynecologic Malignancies
NCT03111992Phase IMultiple Myeloma
NCT01968915Phase I
(Completed)
Advanced Solid Tumors
NCT02098161Phase IIPrimary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocytosis Myelofibrosis
NCT01955434Phase II
(Completed)
Relapsed or Refractory Multiple Myeloma
WX20120108Pre-clinical