Table 2 Summary of metabolic, HIV disease, and liver disease characteristics in HIV/HCV-coinfected patients at baseline and the end of follow-up
Variable–median (IQR) | Baseline | Final | p-value |
|---|---|---|---|
Metabolic profile | |||
Glucose (mg/dL) | 97.5 (83.8; 103) | 93 (86.5; 96.5) | 0.967 |
Triglycerides (mg/dL) | 108 (78.5; 169.5) | 145 (99.5; 189.3) | 0.063 |
Cholesterol (mg/dL) | 169 (139.5; 194.5) | 183.5 (169.8; 208.5) | 0.022 |
LDL (mg/dL) | 104 (76.3; 118.8) | 110 (97; 135) | 0.071 |
HDL (mg/dL) | 48 (36; 56.5) | 36 (33; 50) | 0.119 |
HIV disease profile | |||
CD4+ T-cells/mm3 | 678 (446; 911) | 827 (588; 1131) | 0.026 |
CD8+ T-cells/mm3 | 946 (555; 1356) | 1093 (840; 1308) | 0.531 |
HIV-viral load > 50 copies/mL (%) | 0/28 (0%) | 4/26 (15.4%) | 0.982 |
Liver disease profile | |||
LSM (kPa) | 11.9 (9.6; 19.9) | 7.6 (5.9; 13.9.) | 0.002 |
FIB4 | 2.6 (1.9; 3.2) | 1.7 (1.2; 2.1) | 0.000 |
AST (UI/L) | 61 (42.5; 79.3) | 19 (13.8; 25) | 0.000 |
ALT (UI/L) | 71.5 (56; 100.5) | 33.5 (26.5; 42) | 0.000 |
GGT (UI/L) | 41 (35.5; 44) | 33.5 (26.5; 42) | 0.951 |
Alkaline phosphatase (UI/L) | 94.5 (78; 117) | 95 (85; 120) | 0.381 |
INR | 1 (1; 1.1) | 1 (0.95; 1.1) | 0.353 |
Bilirubin (mg/dL) | 0.6 (0.5; 1.15) | 0.6 (0.4; 0.8) | 0.177 |
Albumin (g/dL) | 4.3 (3.9; 4.6) | 4.5 (4.2; 4.7) | 0.045 |