Table 2 The effects of tetrac derivatives

Cell cycle [5, 59, 89]

Angiogenesis [5, 18, 38, 89]

Others [5, 19, 59, 89, 90]

 CCND1 ↓ (Tetrac, NDAT)

 Anti-angiogenic:

 HIF1A ↓ (tetrac, NDAT)

 THBS1 ↑ (tetrac, NDAT)

 TP53 ↑ (NDAT)

Cell proliferation [5, 19, 38, 59, 89]

 RRM2B ↑ (NDAT)

 CBY1 ↑ (tetrac, NDAT)

 Angiogenic:

 p21 ↑ (NDAT)

 CTNNA1 ↓ (NDAT)

 VEGFA ↓ (tetrac, NDAT)

 CTNNA2 ↓ (NDAT)

 bFGF ↓ (tetrac, NDAT)

 CTNNB1 ↓ (tetrac)

 β-catenin ↓ (tetrac)

Metastasis [5, 89]

 PCNA ↓ (tetrac,  NDAT)

 MMP-2 ↓ (tetrac, NDAT)

 c-Myc ↓ (tetrac, NDAT)

 MMP-9 ↓ (tetrac, NDAT)

 EGFR ↓ (NDAT)

 MMP-13 ↓ (tetrac)

Apoptosis [5, 38, 59, 66]

Immune checkpoint [45]

 Anti-apoptotic:

 PD-L1 ↓ (NDAT)

 MCL1 ↓ (NDAT)

 XIAP ↓ (tetrac, NDAT)

Chemo sensitization [5, 89]

 HMGA2 ↓ (tetrac)

 Proapoptotic:

 ST6Gal1 ↓ (NDAT)

 BCL2L14 ↑ (NDAT)

 CASP2 ↑ (NDAT)

 BAD ↑ (NDAT)