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Table 2 The effects of tetrac derivatives

From: Role of thyroid hormone-integrin αvβ3-signal and therapeutic strategies in colorectal cancers

Cell cycle [5, 59, 89] Angiogenesis [5, 18, 38, 89] Others [5, 19, 59, 89, 90]
 CCND1 ↓ (Tetrac, NDAT)  Anti-angiogenic:  HIF1A ↓ (tetrac, NDAT)
   THBS1 ↑ (tetrac, NDAT)  TP53 ↑ (NDAT)
Cell proliferation [5, 19, 38, 59, 89]    RRM2B ↑ (NDAT)
 CBY1 ↑ (tetrac, NDAT)  Angiogenic:  p21 ↑ (NDAT)
 CTNNA1 ↓ (NDAT)  VEGFA ↓ (tetrac, NDAT)  
 CTNNA2 ↓ (NDAT)  bFGF ↓ (tetrac, NDAT)  
 CTNNB1 ↓ (tetrac)   
 β-catenin ↓ (tetrac) Metastasis [5, 89]  
 PCNA ↓ (tetrac,  NDAT)  MMP-2 ↓ (tetrac, NDAT)  
 c-Myc ↓ (tetrac, NDAT)  MMP-9 ↓ (tetrac, NDAT)  
 EGFR ↓ (NDAT)  MMP-13 ↓ (tetrac)  
Apoptosis [5, 38, 59, 66] Immune checkpoint [45]  
 Anti-apoptotic:  PD-L1 ↓ (NDAT)  
 MCL1 ↓ (NDAT)   
 XIAP ↓ (tetrac, NDAT) Chemo sensitization [5, 89]  
   HMGA2 ↓ (tetrac)  
 Proapoptotic:  ST6Gal1 ↓ (NDAT)  
 BCL2L14 ↑ (NDAT)   
 CASP2 ↑ (NDAT)   
 BAD ↑ (NDAT)