From: Recent developments in epigenetic cancer therapeutics: clinical advancement and emerging trends
E3 ligases | Tissue expression of E3 ligases |
---|---|
CRBN | Highly expressed in adrenal gland, appendix, bronchus, cerebellum, cerebral cortex, colon duodenum, heart muscle, liver, lung, lymph node, oral mucosa, pancreas, parathyroid gland, placenta, salivary gland, soft tissue 1, thymus thyroid gland, tonsil, vagina |
MDM2 | Highly expressed in adrenal gland, appendix, bone marrow, breast, bronchus, caudate, cerebellum, cerebral cortex, cervix uterine, colon, duodenum, endometrium, epididymis, oesophagus, eye, gall bladder, hippocampus, heart muscle, kidney, liver, lung, lymph node, nasopharynx, oral mucosa, ovary, pancreas, parathyroid gland, placenta, prostate, rectum, salivary gland, seminal vesicle, skeletal muscle, skin, small intestine, smooth muscle, soft tissue 1, soft tissue 2, spleen, stomach, testis, thymus, thymus thyroid gland, tonsil, urinary bladder, vagina |
XIAP | Highly expressed in adrenal gland, heart muscle, hippocampus, seminal vesicle, tonsil |
VHL | High expressed in gall bladder, kidney Moderately expressed in salivary gland, liver, pancreas, epididymis, |