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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

Fig. 1

MSC sources and clinical indications in clinical studies. As of October 11, 2020, 1,242 registered studies were identified on clinicaltrials.gov by searching keywords “mesenchymal stem cell” or “mesenchymal stromal cell” (Additional file 1). After excluding studies with no longer available/ suspended/ temporarily not available/ terminated/ unknown/ withdrawn status, unknown phase information, and studies that did not use MSCs in their intervention arm, 639 studies remained. Nine of these 639 studies investigated MSCs from two tissue origins, generating a total of 648 studies for analysis. a Tissue origins of MSCs in clinical studies, b number of MSC-related clinical studies by medical specialty, and c the top 20 disease indications of MSC-related clinical studies

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