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Fig. 5 | Journal of Biomedical Science

Fig. 5

From: Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

Fig. 5

Workflow of fluorescent nanodiamond (FND)-labelled tracking platform and biodistribution analysis of FND-labelled pcMSCs. a The FND-labelled tracking platform for cell biodistribution analysis. This platform can provide analysis for transplanted cell localization, pharmacokinetics (PK), and pharmacodynamics (PD). FND-labelled cells are delivered through intravenous injection. The transplanted cells can be pinpointed to specific locations with background-free imaging by Leica SP8 microscopy using a time-gating technique. PK and PD analyses can be performed with a magnetic modulation fluorescence (MMF) machine after tissue/organ digestion. b Distribution of FND-labelled pcMSCs among different organs in a healthy mouse model. Experiments were repeated in triplicate and error bars represent the standard deviation

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Journal of Biomedical Science

ISSN: 1423-0127