Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

Table 2 MSC secreted factors involved in tumor promotion

Factors involved in tumor promotion
Cytokines	IL6, TGF-β1, IL-8	[125, 132, 133, 139, 147, 150, 159, 162, 165]
Chemokines	SDF-1, CXCL1, CCL2, CCL5	[123, 124, 136, 142,143,144, 150, 160, 162]
Angiogenic factors	VEGF, Ang-1, PDGF, IGF	[148, 162]
Growth factor	NRG1	[135]
Other factors	periostin, PAI-1, Sema-7A	[134, 162]
microRNAs	miR-21-5p, miR-410, MiR-142-3p, miR-23b	[126, 136, 145, 158]

ISSN: 1423-0127